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ID 112815
タイトル別表記
Melatonin inhibits CXCL10 and MMP-1 production
著者
Shindo, Satoru Tokushima University
キーワード
melatonin
CXCL10
MMP-1
periodontal ligament cells
資料タイプ
学術雑誌論文
抄録
Melatonin is a hormone that is mainly secreted by the pineal gland and exhibits a wide spectrum of activities, including antioxidant functions. Melatonin has been detected in gingival crevicular fluid. However, the role of melatonin in periodontal tissue is still uncertain. The aim of this study was to examine the effects of melatonin on inflammatory mediator expression in human periodontal ligament cells (HPDLC).
Interleukin (IL)-1β induced CXC chemokine ligand (CXCL)10, matrix metalloproteinase (MMP)-1, and tissue inhibitors of metalloproteinase (TIMP)-1 production in HPDLC. Melatonin decreased CXCL10 and MMP-1 production and increased TIMP-1 production in IL-1β-stimulated HPDLC. Western blot analysis showed that melatonin inhibited p38 mitogen-activated protein kinase (MAPK) and c-jun N-terminal kinase (JNK) phosphorylation, and IκB-α degradation and phosphorylation in IL-1β-stimulated HPDLC. These results suggest that melatonin might inhibit Th1 cell migration by reducing CXCL10 production. Moreover, melatonin might inhibit soft tissue destruction by decreasing MMP-1 production in periodontal lesions.
掲載誌名
Inflammation
ISSN
03603997
15732576
cat書誌ID
AA00673765
AA12117940
出版者
Springer
39
4
開始ページ
1520
終了ページ
1526
発行日
2016-06-06
備考
This is a post-peer-review, pre-copyedit version of an article published in Inflammation.
The final authenticated version is available online at: https://doi.org/10.1007/s10753-016-0386-3
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
歯学系