ID 109802
タイトルヨミ
シェーグレン ショウコウグン ニ タイスル ビョウキ タイオウガタ テーラーメード イリョウ ノ コウチク
タイトル別表記
Establishment of a Tailor-made Therapy Based on the Disease-stage of Sjögren's Syndrome
著者
東, 雅之 徳島大学大学院ヘルスバイオサイエンス研究部口腔内科学分野 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
唾液腺
口腔乾燥症
腺房細胞
導管細胞
資料タイプ
学術雑誌論文
抄録
Sjögren's syndrome (SS) is one of the most common rheumatic diseases. Histopathologic features of SS salivary glands include: (a) the eventual total replacement of the acinar structure by marked lymphocytic infiltrate and (b) the occurrence of various changes in the ductal structure within infiltrated areas, such as metaplasia, hyperplasia, thinning of ductal layer, or oncocytic change, and in some cases the formation of epimyoepithelial islands arising from ductal proliferation. Accordingly, surviving and/or proliferating ductal cells in SS salivary glands may be regarded as one of the possible sources for the improvement of salivary secretion. Thus far, I found that inhibition of TNF-α-induced MMP-9 production in acinar cells lead to restored integrity of the acinar structure in SS salivary glands. Therefore, in this review I would like to postulate a tailor-made therapy based on the diseasestage of SS. First, therapy for the inhibition of lymphocytic infiltrate into salivary glands by regulating balance of sex hormones in acinar cells (early stage of SS); second, therapy for the maintenance of stable acinar structure by inhibiting cytokine-induced basement membrane-degrading enzymes, such as MMP-9 (intermediate stage of SS); and third, therapy for the bestowal of ability to secrete saliva on ductal cells (late stage of SS). Hopefully, these disease stage-specific therapies would contribute to the improvement of QOL of SS patients.
掲載誌名
四国歯学会雑誌
ISSN
09146091
cat書誌ID
AN10050046
出版者
四国歯学会
23
2
開始ページ
85
終了ページ
89
並び順
85
発行日
2011-01-31
EDB ID
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
歯学系