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ID 117529
タイトル別表記
ヒト白血病K562細胞におけるアドリアマイシン作用のクレモフォールELによる修飾
著者
松井, 寛子 The University of Tokushima
坂梨, 容子 The University of Tokushima
西村, 優美子 The University of Tokushima
堀本, かんな The University of Tokushima
石田, 志朗 Tokushima Bunri University
岡野, 善郎 Tokushima Bunri University
小山, 保夫 The University of Tokushima KAKEN研究者をさがす
キーワード
adriamycin
cremophor EL
cytotoxicity
human leukemia K562 cells
資料タイプ
紀要論文
抄録
Adriamycin and paclitaxel are simultaneously used for cancer treatment in some cases. The formula of paclitaxel contains cremophor EL as a solvent. Since this solvent exerts diverse biological actions, the modification of adriamycin action by cremophor EL has been studied on human leukemia K562 cells. Cremophor EL did not significantly affect the concentration-response relation for antiproliferative action of adriamycin and the cell cycle changed by adriamycin. However, the induction of morphological change by adriamycin was significantly augmented by cremophor EL. The simultaneous application of cremophor EL increased the intensity of fluorescence from adriamycin trapped inside the cells in a concentration-dependent manner, suggesting an increase in intracellular concentration of adriamycin by cremophor EL. Adriamycin alone at concentrations higher than those to completely inhibit the growth induced morphological change in K562 cells. Therefore, cremophor EL may potentiate some of actions induced by adriamycin when adriamycin and paclitaxel are simultaneously applied.
掲載誌名
自然科学研究
ISSN
09146385
cat書誌ID
AN10065859
出版者
徳島大学総合科学部
21
開始ページ
9
終了ページ
17
並び順
9
発行日
2007-12-21
EDB ID
フルテキストファイル
nsr_21_9.pdf 1.51 MB
言語
eng
著者版フラグ
出版社版
部局
生物資源系