ID 106020
著者
柴田, 洋文 Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
ニシタニ, ノリコ Graduate School of Pharmaceutical Sciences, the University of Tokushima
ヤオハラ, サユリ Graduate School of Pharmaceutical Sciences, the University of Tokushima
新垣, 尚捷 Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
樋口, 富彦 Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
川添, 和義 Department of Clinical Pharmacy, Institute of Health Biosciences, the University of Tokushima Graduate School|Division of Pharmacy, Tokushima University Hospital KAKEN研究者をさがす
水口, 和生 Department of Clinical Pharmacy, Institute of Health Biosciences, the University of Tokushima Graduate School|Division of Pharmacy, Tokushima University Hospital 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
statin
bacterial translocation
MDCK
P. aeruginosa
資料タイプ
学術雑誌論文
抄録
Pseudomonas aeruginosa causes both invasive (bacteremic) and chronic noninvasive infections. An increase in intestinal epithelial permeability is a characteristic of severe sepsis. Alterations in the normal barrier function of the gut mucosa may result in the translocation of microbial cells and products. On the otherhand, it has been demonstrated that statin use is associated with a lower risk of mortality from bloodstream infections. Therefore, we investigated the ability of P. aeruginosa PAO1 to translocate across the Madin-Darby canine kidney (MDCK) cell monolayers in the presence and absence of simvastatin. The bacteria readily translocated across MDCK cell monolayers after 3 h of infection irrespective of the presence or absence of the drug in the medium. However, the bacteria were less able to penetrate the MDCK monolayers in the presence of simvastatin than in its absence. A gentamicin survival assay demonstrated that simvastatin did not affect the bacteria’s invasive behavior in the MDCK cells.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
59
1-2
開始ページ
186
終了ページ
191
並び順
186
発行日
2012-02
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
薬学系
医学系