ID 83493
著者
イワノ, ジュンコ Department of Clinical Pharmacology, The University of Tokushima Faculty of Pharmaceutical Sciences
ナカムラ, ヨウイチ Third Department of Internal Medicine, The University of Tokushima School of Medicine
イズミダ, タカシ Department of Clinical Pharmacology, The University of Tokushima Faculty of Pharmaceutical Sciences
ヨコタ, マサユキ Department of Clinical Pharmacology, The University of Tokushima Faculty of Pharmaceutical Sciences
滝口, 祥令 Department of Clinical Pharmacology, The University of Tokushima Faculty of Pharmaceutical Sciences 徳島大学 教育研究者総覧 KAKEN研究者をさがす
水口, 和生 Division of Pharmacy, University Hospital, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
曽根, 三郎 Third Department of Internal Medicine, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
theophylline
creatine kinase
drug interaction
資料タイプ
学術雑誌論文
抄録
An increase in the serum creatine kinase (CK) level is one of the side effects of theophylline;on rare occasions, the increase may be followed by rhabdomyolysis. Theophylline is often administered with drugs that potentially elevate the serum CK level (CK-elevating drugs) such as β-agonists and steroids. However, the effects of the combined treatment of theophylline and CK-elevating drugs have not been reported. We, therefore, retrospectively investigated the effects of combined treatment on the serum CK level, in391asthmatic outpatients.
In this study, the number and type of the CK-elevating drugs administered, and the serum levels of CK and theophylline, were investigated. The patients were divided into four groups:the theophylline-treated and CK-elevating drug-treated group, the theophylline-treated and non-CK-elevating drug-treated group, the non-theophylline-treated and CK-elevating drug-treated group, and the non-theophylline-treated and non-CK-elevating drug-treated group.
The theophylline-treated and CK-elevating drug-treated group showed about 100%higher serum CK levels (225IU/L) than any other group (102-124IU/L), and no increase in the serum theophylline level. This result indicates that there is a synergistic effect of theophylline and CK-elevating drugs on the serum CK level.
The combined treatment of theophylline and CK-elevating drugs induces a synergistic increase in the serum CK level, indicating not pharmacokinetic but pharmacodynamic interactions with these drugs.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
47
1-2
開始ページ
9
終了ページ
13
並び順
9
発行日
2000
備考
フルテキストファイル
言語
eng
部局
薬学系
医学系