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ID 113939
著者
Kujime, Eiko Tokushima University|Matsuyama University
Tanaka, Hiroko Tokushima University
キーワード
Stereogenic phosphorus atom
Methyl bis(2,2,2-trifluoroethyl)phosphonoacetate
Horner-Wadsworth-Emmons reagent
Kinetic resolution
Enzymatic hydrolysis
資料タイプ
学術雑誌論文
抄録
In this data article, we describe the enzymatic kinetic resolution of a series of racemic mixed phosphonoacetates, which were successfully prepared from methyl bis(2,2,2-trifluoroethyl)phosphonoacetate (Still-Gennari reagent) by alcoholysis with σ-symmetrical secondary alcohols in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). Porcine liver esterase (PLE)-catalyzed kinetic resolution of some of these racemic mixed phosphonoacetates proceeded in a highly stereoselective manner to furnish the chiral P-stereogenic phosphonoacetates (up to >99% ee).
掲載誌名
Chemical Data Collections
ISSN
24058300
出版者
Elsevier
5-6
開始ページ
12
終了ページ
20
発行日
2016-09-16
権利情報
© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
出版社版DOI
出版社版URL
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言語
eng
著者版フラグ
著者版
部局
薬学系
技術支援部