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ID 116689
著者
Yamasaki, Yuki Tokushima University
Takeo, Jiro Nippon Suisan Kaisha
Miyahara, Hiroko Nippon Suisan Kaisha
Sebe, Mayu Tokushima University
板東, 正浩 Tokushima University
Tanba, Yousuke Tokushima University
Mishima, Yuna Tokushima University
Takeji, Kana Tokushima University
Ueshima, Nanako Tokushima University
升本, 早枝子 Tokushima University
Yoshimoto, Ryoko Tokushima Prefectural Industrial Technology Centre
Tsutsumi, Yasuo M Hiroshima University
資料タイプ
学術雑誌論文
抄録
Fish oil-derived long-chain monounsaturated fatty acids (LCMUFAs) with a carbon chain length longer than 18 units ameliorate cardiovascular risk in mice. In this study, we investigated whether LCMUFAs could improve endothelial functions in mice and humans. In a double-blind, randomized, placebo-controlled, parallel-group, multi-center study, healthy subjects were randomly assigned to either an LCMUFA oil (saury oil) or a control oil (olive and tuna oils) group. Sixty subjects were enrolled and administrated each oil for 4 weeks. For the animal study, ApoE−/− mice were fed a Western diet supplemented with 3% of either gadoleic acid (C20:1) or cetoleic acid (C22:1) for 12 weeks. Participants from the LCMUFA group showed improvements in endothelial function and a lower trimethylamine-N-oxide level, which is a predictor of coronary artery disease. C20:1 and C22:1 oils significantly improved atherosclerotic lesions and plasma levels of several inflammatory cytokines, including IL-6 and TNF-α. These beneficial effects were consistent with an improvement in the gut microbiota environment, as evident from the decreased ratio of Firmicutes and/ or Bacteroidetes, increase in the abundance of Akkermansia, and upregulation of short-chain fatty acid (SCFA)-induced glucagon-like peptide-1 (GLP-1) expression and serum GLP-1 level. These data suggest that LCMUFAs alter the microbiota environment that stimulate the production of SCFAs, resulting in the induction of GLP-1 secretion. Fish oil-derived long-chain monounsaturated fatty acids might thus help to protect against cardiovascular disease.
掲載誌名
Translational Research
ISSN
19315244
cat書誌ID
AA12149426
AA12796875
出版者
Elsevier
237
開始ページ
16
終了ページ
30
発行日
2021-03-26
権利情報
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系