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ID 114642
タイトル別表記
UVA-LED照射装置を用いた、基質特異性拡張型βラクタマーゼ産生大腸菌の殺菌
Inactivation of ESBL-E. coli
著者
ウルファ, マリア 徳島大学大学院栄養生命科学教育部(人間栄養科学専攻)
Sato, Masami Tokushima University
Fukushima, Shiho Tokushima University
Kido, Junko Tokushima University
キーワード
extended-spectrum β-lactamase (ESBL)
ESBL-E. coli
E. coli
UVA-LED irradiation
資料タイプ
学位論文
抄録
The prevalence of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli is increasing rapidly and spreading worldwide, particularly in Asia, compared to other regions. In the last ten years, in our hospital, in particular, there has been a < 30% increase. To prevent the spread of ESBL in hospitals and the community, the ultraviolet (UV) A-light-emitting diode (LED) irradiation device was used to inactivate ESBL-E. coli in human livestock and the environment. ESBL-E. coli and E. coli bacterial samples were collected from patients at Tokushima University Hospital (Tokushima City, Japan). The UVA-LED irradiation system had 365 nm single wavelength, and the current of the circuit was set to 0.23 or 0.50 A consistently. Results demonstrated that UVA-LED was useful for the inactivation of ESBL-E. coli and E. coli. The minimum energy dosage required to inactivate ESBL-E. coli and E. coli was 40.76 J/cm2 (45 min) in the first type of UVA-LED and 38.85 J/cm2 (5 min) in the second type. There were no significant differences between ESBL-E. coli and E. coli. The inactivation of ESBL-E. coli was dependent on energy. These findings suggest that UVA-LED with 365 nm single wavelength could be useful for surface decontamination in healthcare facilities.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA12022913
AA11166929
出版者
Tokushima University Faculty of Medicine
67
1-2
開始ページ
163
終了ページ
169
並び順
163
発行日
2020-02
備考
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Maria Ulfaの学位論文として提出され, 学位審査・授与の対象となっている。
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3410号
学位記番号
甲栄第271号
学位授与年月日
2020-03-23
学位名
博士(栄養学)
学位授与機関
徳島大学
部局
病院
医学系
理工学系