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ID 114969
タイトル別表記
Prognostic value of partial-EMT-related genes in head and neck squamous cell carcinoma by a bioinformatic analysis
Prognostic value of p-EMT-related genes in HNSCC
著者
Kisoda, Satoru Tokushima University
Shao, Wenhua Tokushima University
Jin, Shengjian Tokushima University
キーワード
partial-epithelial-to-mesenchymal transition
head and neck squamous cell carcinoma
prognosis
資料タイプ
学術雑誌論文
抄録
Objective: Recent studies have revealed that the ability of cancer cells to undergo intermediate state of EMT, partial EMT (p-EMT) poses a higher metastatic risk rather than complete EMT. Here we examined the prognostic value of p-EMT-related genes in head and neck squamous cell carcinoma (HNSCC) by bioinformatics approaches.
Materials and Methods: We used RNA-seq data of 519 primary HNSCC cases obtained from TCGA database. We compared the expression of p-EMT-related genes in HNSCC tissues with normal tissues. We evaluated the prognostic value of p-EMT-related genes in HNSCC cases by Log-rank test. We examined the expression of p-EMT-, EMT-, and epithelial differentiation-related genes by qPCR.
Results: Among p-EMT-related genes that were highly expressed in HNSCC cases, high expression of SERPINE1, ITGA5, TGFBI, P4HA2, CDH13, and LAMC2 was significantly correlated with poor survival of HNSCC patients. By gene expression pattern, HNSCC cell lines were classified into three groups; epithelial phenotype, EMT-phenotype, and p-EMT phenotype.
Conclusions: Our findings suggest that p-EMT program may be involved in poor prognosis of HNSCC. SERPINE1, ITGA5, TGFBI, P4HA2, CDH13, and LAMC2 can be used for a prognostic marker. Moreover, HNSCC cells with p-EMT phenotype can be a useful model for investigating a nature of p-EMT.
掲載誌名
Oral Diseases
ISSN
16010825
cat書誌ID
AA11631042
出版者
John Wiley & Sons
26
6
開始ページ
1149
終了ページ
1156
発行日
2020-04-11
備考
論文本文は2021-04-29以降公開予定
権利情報
This is the peer reviewed version of the following article: Kisoda, S, Shao, W, Fujiwara, N, et al. Prognostic value of partial EMT‐related genes in head and neck squamous cell carcinoma by a bioinformatic analysis. Oral Dis. 2020; 26: 1149– 1156., which has been published in final form at https://doi.org/10.1111/odi.13351. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
EDB ID
出版社版DOI
出版社版URL
言語
eng
著者版フラグ
その他
部局
歯学系
医学系