直近一年間の累計
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ID 116318
著者
Tu, Trang TH Tokyo Medical and Dental University
Miura, Anna Tokyo Medical and Dental University
Shinohara, Yukiko Tokyo Medical and Dental University
Mikuzuki, Lou Tokyo Medical and Dental University
Kawasaki, Kaoru Tokyo Medical and Dental University
Sugawara, Shiori Tokyo Medical and Dental University
Suga, Takayuki Tokyo Medical and Dental University
Aota, Yuma Tokyo Medical and Dental University
Umezaki, Yojiro Fukuoka Dental College
Takenoshita, Miho Tokyo Medical and Dental University
Toyofuku, Akira Tokyo Medical and Dental University
キーワード
atypical odontalgia
orofacial chronic pain
depression
pain catastrophizing
tricyclic antidepressant
atypical antipsychotic
資料タイプ
学術雑誌論文
抄録
Objectives: There has been considerable research which has focused on clarifying the origin of pain in patients with atypical odontalgia (AO), also known as “idiopathic toothache”, and on identifying effective treatment, but there has been limited success so far. In this study, we assessed the outcomes of treatment and attempted to identify factors that could account for pain remission in patients with AO.
Patients and methods: Data for 165 patients diagnosed with AO from June 2015 to August 2017 were retrospectively reviewed. The patients’ sex, age, duration of pain, and psychiatric history were collected, along with information on pain intensity, depressive status, and catastrophizing scores. Responses at 4 and 16 weeks from the start of treatment were observed. The associations between potentially associated factors and outcome were investigated using Bayesian model averaging.
Results: A 30% reduction in pain was reported by 38 patients (46.3%) at 4 weeks and by 54 patients (65.9%) at 16 weeks. The pain intensity decreased as the depression and catastrophizing score improved; all of the changes were statistically significant (P<0.001). Four elements, that is, patient sex, depression score at baseline, pain score at 4 weeks, and change in the catastrophizing score, explained 52.5% of the variation in final outcome between individual patients.
Conclusion: Our findings confirm the efficacy of tricyclic antidepressants (TCAs) as a treatment for AO and indicate that other medications, especially aripiprazole used in combination with a TCA, may be useful. A considerable number of patients, especially women, those with lower levels of depression at baseline, and those who responded to 4 weeks of treatment, achieved pain relief.
掲載誌名
Journal of Pain Research
ISSN
11787090
出版者
Dove Medical Press
12
開始ページ
831
終了ページ
839
発行日
2019-02-27
権利情報
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
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言語
eng
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部局
医学系