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タイトル別表記
2種類の正常眼圧緑内障モデルマウスに対するN-アセチルシステインの網膜変性抑制効果の違い
著者
佐埜, 弘樹 徳島大学大学院医科学教育部(医学専攻)
Namekata, Kazuhiko Tokyo Metropolitan Institute of Medical Science
Kimura, Atsuko Tokyo Metropolitan Institute of Medical Science
Shitara, Hiroshi Tokyo Metropolitan Institute of Medical Science
Guo, Xiaoli Tokyo Metropolitan Institute of Medical Science
Harada, Chikako Tokyo Metropolitan Institute of Medical Science
Harada, Takayuki Tokyo Metropolitan Institute of Medical Science|Tokushima University
キーワード
N-acetylcysteine
NTG
oxidative stress
EAAC1
GLAST
資料タイプ
学位論文
抄録
N-acetylcysteine (NAC) is widely used as a mucolytic agent and as an antidote to paracetamol overdose. NAC serves as a precursor of cysteine and stimulates the synthesis of glutathione in neural cells. Suppressing oxidative stress in the retina may be an effective therapeutic strategy for glaucoma, a chronic neurodegenerative disease of the retinal ganglion cells (RGCs) and optic nerves. Here we examined the therapeutic potential of NAC in two mouse models of normal tension glaucoma, in which excitatory amino-acid carrier 1 (EAAC1) or glutamate/aspartate transporter (GLAST) gene was deleted. EAAC1 is expressed in retinal neurons including RGCs, whereas GLAST is mainly expressed in Müller glial cells. Intraperitoneal administration of NAC prevented RGC degeneration and visual impairment in EAAC1-deficient (knockout; KO) mice, but not in GLAST KO mice. In EAAC1 KO mice, oxidative stress and autophagy were suppressed with increased glutathione levels by NAC treatment. Our findings suggest a possibility that systemic administration of NAC may be available for some types of glaucoma patients.
掲載誌名
Cell Death & Disease
ISSN
20414889
出版者
Springer Nature
10
開始ページ
75
発行日
2019-01-28
備考
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Hiroki Sanoの学位論文として提出され, 学位審査・授与の対象となっている。
権利情報
© The Author(s) 2019
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3371号
学位記番号
甲医第1454号
学位授与年月日
2020-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系