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ID 112405
著者
駒, 貴明 University of Texas Medical Branch|Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Veljkovic, Veljko Biomed Protection
Anderson, Danielle E. Duke-NUS Medical School
Wang, Lin-Fa Duke-NUS Medical School
Rossi, Shannan L. University of Texas Medical Branch
Shan, Chao University of Texas Medical Branch
Shi, Pei-Yong University of Texas Medical Branch
Beasley, David W. University of Texas Medical Branch
Bukreyeva, Natalya University of Texas Medical Branch
Smith, Jeanon N. University of Texas Medical Branch
Hallam, Steven University of Texas Medical Branch
Huang, Cheng University of Texas Medical Branch
von Messling, Veronika Duke-NUS Medical School|Paul-Ehrlich-Institute
Paessler, Slobodan University of Texas Medical Branch
資料タイプ
学術雑誌論文
抄録
Zika virus (ZIKV) causes mostly asymptomatic infection or mild febrile illness. However, with an increasing number of patients, various clinical features such as microcephaly, Guillain-Barré syndrome and thrombocytopenia have also been reported. To determine which host factors are related to pathogenesis, the E protein of ZIKV was analyzed with the Informational Spectrum Method, which identifies common information encoded by primary structures of the virus and the respective host protein. The data showed that the ZIKV E protein and the complement component C1q cross-spectra are characterized by a single dominant peak at the frequency F = 0.338, suggesting similar biological properties. Indeed, C1q-specific antibodies were detected in sera obtained from mice and monkeys infected with ZIKV. As C1q has been known to be involved not only in immunity, but also in synaptic organization and different autoimmune diseases, a ZIKV-induced anti-C1q antibody response may contribute to the neurological complications. These findings might also be exploited for the design of safe and efficacious vaccines in the future.
掲載誌名
Scientific Reports
ISSN
20452322
出版者
Springer Nature
8
開始ページ
1882
発行日
2018-01-30
備考
Dataset : srep_8_1882_s1.xlsx
権利情報
© The Author(s) 2018
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系