ID 110819
著者
サンノミヤ, カツタカ Department of Digestive and Cardiovascular Medicine, The University of Tokushima Graduate School
ホンダ, ヒロヒト Department of Digestive and Cardiovascular Medicine, The University of Tokushima Graduate School
クボ, ケンイチロウ Department of Digestive and Cardiovascular Medicine, The University of Tokushima Graduate School
イイ, クニオ Department of Digestive and Cardiovascular Medicine, The University of Tokushima Graduate School
Yuan, Ying Department of Digestive and Cardiovascular Medicine, The University of Tokushima Graduate School
アオヤギ, エリコ Department of Digestive and Cardiovascular Medicine, The University of Tokushima Graduate School
六車, 直樹 Department of Digestive and Cardiovascular Medicine, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
シミズ, イチロウ Department of Digestive and Cardiovascular Medicine, The University of Tokushima Graduate School
伊東, 進 Department of Digestive and Cardiovascular Medicine, The University of Tokushima Graduate School 徳島大学 教育研究者総覧
キーワード
guanase
nedasin
rat
human
資料タイプ
学術雑誌論文
抄録
Human guanase is known as a specific enzyme in the liver, kidney, and brain. However, its functional significance remains poorly understood. In addition, interestingly, a different organ distribution between humans and rats was suggested. Here, we performed immunohistochemical staining with anti-human nedasin (neuronal and endocrine discs large/SAP102 associated protein), whose sequence was identical to that of guanase, antibody and histochemical staining for guanase in normal tissues of rat and human liver, kidney, and small intestine, and compared the results. Guanase activity was observed uniformly in the rat hepatocytes, biliary epithelium and vascular endothelium cells, while it was localized to the hepatocytes and biliary epithelium in the human liver. When the histochemical staining for guanase and the immunohistochemical staining for nedasin were compared, the stained regions were different in the rat liver but were almost consistent in all human tissues. Totally consistent staining results were also obtained between rats and humans in the other organization except the liver. Based upon the research reports to date, the experiments on guanase and nedasin in rat organs performed in this study are considered to have important implications in the investigation of their physiological significance.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
53
3-4
開始ページ
246
終了ページ
254
並び順
246
発行日
2006-08
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系