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ID 113578
タイトル別表記
Role of periostin
著者
Conway, Simon J. Indiana University
Izuhara, Kenji Saga Medical School
Litvin, Judith Temple University
Markwald, Roger Medical University of South Carolina
Ouyang, Gaoliang Xiamen University
Arron, Joseph R. Genentech
Holweg, Cecile T. J. Genentech
Kudo, Akira Tokyo Institute of Technology
キーワード
Periostin
Extracellular matrix
Remodeling
Repair
資料タイプ
学術雑誌論文
抄録
Periostin, also termed osteoblast-specific factor 2, is a matricellular protein with known functions in osteology, tissue repair, oncology, cardiovascular and respiratory systems, and in various inflammatory settings. However, most of the research to date has been conducted in divergent and circumscribed areas meaning that the overall understanding of this intriguing molecule remains fragmented. Here, we integrate the available evidence on periostin expression, its normal role in development, and whether it plays a similar function during pathologic repair, regeneration, and disease in order to bring together the different research fields in which periostin investigations are ongoing. In spite of the seemingly disparate roles of periostin in health and disease, tissue remodeling as a response to insult/injury is emerging as a common functional denominator of this matricellular molecule. Periostin is transiently upregulated during cell fate changes, either physiologic or pathologic. Combining observations from various conditions, a common pattern of events can be suggested, including periostin localization during development, insult and injury, epithelial–mesenchymal transition, extracellular matrix restructuring, and remodeling. We propose mesenchymal remodeling as an overarching role for the matricellular protein periostin, across physiology and disease. Periostin may be seen as an important structural mediator, balancing appropriate versus inappropriate tissue adaption in response to insult/injury.
掲載誌名
Cellular and Molecular Life Sciences
ISSN
14209071
1420682X
cat書誌ID
AA11619003
AA11112963
出版者
Springer Nature
71
7
開始ページ
1279
終了ページ
1288
発行日
2013-10-22
権利情報
This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系