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ID 110820
著者
シモオカ, リエ Department of Nutrition and Health Promotion, Faculty for Human Life Science, Hiroshima Jogakuin University
キド, ヤスヒロ Department of Food Sciences and Nutritional Health, Faculty of Human Environment, Kyoto Prefectural University
チバ, ナオコ Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School
タナカ, ジュンコ Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School
六反, 一仁 Department of Stress Science, Institute of Proteomics Medical Science, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
フロチ, ハルミ Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School
平坂, 勝也 Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School KAKEN研究者をさがす
ニカワ, タケシ Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キシ, キョウイチ Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
cystathionine γ-lyase
methionine
portacaval shunted rats
soy protein diet
資料タイプ
学術雑誌論文
抄録
In hepatic disorders, abnormal plasma amino acid profiles are observed. In this study, we examined whether soy protein isolate (SPI) improved plasma methionine concentration in the model animals. Portacaval shunt (PCS) increased alanine aminotransferase (ALT) activity and methionine concentration in blood of rats fed a 40% casein diet supplemented with 0.6% methionine (casein-M diet). A 40% SPI diet supplemented with 1.28% methionine (SPI-M diet), which contained the same amount of methionine as that in 40% casein-M diet, normalized plasma ALT activity and methionine level in PCS rats. These effects of a SPI diet may be due to its amino acid composition, since an amino acid mixture diet mimicking a 40% SPI-M diet was also effective to hypermethioninemia of PCS rats. To find key enzymes for the beneficial effect of soy protein, we examined effects of a 40% SPI-M or casein-M diet on the activities of three methionine-metabolizing enzymes in liver of PCS rats. A SPI-M diet stimulated only the activity of cystathionine γ-lyase, compared with a casein-M diet. A SPI diet has a preventive effect on hypermethioninemia, at least in part, by stimulating cystathionine γ-lyase activity in liver and may be used for nutritional management of liver disorders with hypermethioninemia.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
53
3-4
開始ページ
255
終了ページ
263
並び順
255
発行日
2006-08
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系