酸化マグネシウムの血中Mg 濃度および腎機能に及ぼす影響について

Last year it was reported that the side effects by magnesium oxide（MgO）were noticed on chronic kidney disease（CKD）, and then to estimate serum Mg concentration and kidney functions in outpatients, that is group（n＝７１）to be treated with MgO（１．６８g／day）, untreated control group （n＝１２９）and group（n＝２４）of Warfarin treatment were examined. Moreover, out of２７treated subjects serum levels of clinical parameters, such as serum uric acid, BUN, creatinine, Ca, P, Mg （mg／dl）and GFR（ml／min／１．７３２）were studied before and after treatment. Serum Mg concentration of treated, untreated and Warfarin group were ２．５１±０．２９＊,２．３８±０．２２and２．２４±０．２４＊＊ mg／dl respectively, the former* was higher and the latter** was lowered. To compare with GFR ≧ ６０and ＜６０serum magnesium was only elevated in the latter with CKD to be treated with MgO. What’ s more discontinued group were gradually lowered serum Mg（2.63±０．２１to２．４７±０．１４）, Ca and P in２７treated group. From these results it was partly suspected that MgO was affected to serum electrolyte in outpatients, therefore some patients with CKD were a little observed clinical examinations and symptoms, but these patients with GFR ≧６０were not so anxious concerned.