2型糖尿病患者の尿中アルブミンおよび尿中IV型コラーゲンに関する臨床的検討 : どちらが糖尿病性早期腎症の発見に有用か

It is important that the control and the detect of diabetic early nephropathy are the first step of the protect of diabetic complications. In this study, in order to determine to be useful the predictor of diabetic nephropathy urinary albumin (creatinine ratio) and urinary type IV collagen were measured by LA and EIA methods in type 2 diabetes mellitus. The subjects are 215 patients with type 2 diabetes mellitus (Age : 65.9±10.8 yo.,Onset : 53.0±11.8 yo., Duration : 12.8±9.8 ys., BMI : 24.0±3.3 kg/m/m., HbA1c : 7.5±1.7%), and then urinary albumin (sigle voided) and urinary type IV collagen levels (first voided morning urine) were 116.0±294.2 mg/g. Cr and 5.88±4.20 g/g. Cr (mean±SD) respectively. To have compared with urinay albumin and urinary type IV collagen by treatments on the each groups, there were gradually increased Diat group < Glibenclamide (SU) group < Insulin therapy group, furthermore the factor of age ran pararell with clinial courses, but the duration of diabetes were not related with these proteinuria. The positive ratio of single voided urinary albumin in no clinical proteinuria were 18.3%, 11.0% for urinary type IV collagen, while in the diet group to be thought about the early stage of diabetic nephropathy, it’s positive ratio of urinary albumin were 52.5% and 38.5% for type IV urinary collagen respectively. Accordingly, in order to find out the early stage of diabetic nephropathy the sensitivity of the former was more than the later. These results sugest that the maker as the progreesion of early diabetic nephropathy might be useful to measure the single voided urinary albumin in comparrison with urinary type IV collagen.