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ID 111127
タイトル別表記
5/6腎摘マウスの腎臓におけるミトコンドリア呼吸鎖複合体の不均衡
Renal mitochondrial complex in 5/6 Nx mice
著者
中下, 幸江 徳島大学大学院栄養生命科学教育部(人間栄養科学専攻)
Sano, Tomoya Takeda Pharmaceutical Company
Yoshioka, Hiroaki Takeda Pharmaceutical Company
Shimada, Tomoki Takeda Pharmaceutical Company
Hori, Ryotaro Takeda Pharmaceutical Company
Usami, Makoto Kobe University
キーワード
db/m-5/6 nephrectomized mice
db/db mice
glomerular hyperfiltration
mitochondrial respiratory complex
資料タイプ
学位論文
抄録
Hyperglycemia induces nonconcordant regulation of renal mitochondrial respiratory complexes, increases oxidative stress, and causes diabetic nephropathy. Hypertension is a complication associated with diabetes and involves glomerular hyperfiltration, the effects of which on mitochondrial respiratory complexes are not well understood. To investigate the effect of glomerular hyperfiltration on renal mitochondrial respiratory complexes, we used the 5/6 nephrectomized BKS.Cg-Dock7m+/+Leprdb/J, Dock7m+/+Leprdb mice (db/m-5/6Nx mice) as a model for glomerular hyperfiltration. The BKS.Cg-Dock7m+/+Leprdb/J, +Leprdb/+Leprdb mice (db/db mice), a model for type 2 diabetes, was used as the positive control. We investigated the activities and protein levels of the mitochondrial complex, and themitochondrial DNA and adenosine triphosphate content in the kidneys of these models. Blood chemistry and renal histopathological examination were performed for characterization of the disease. Both models showed expansion of the mesangial matrix of the glomeruli, which is indicative of glomerular hyperfiltration. The activities of complexes I and IV and the protein levels of complexes I and III were nonconcordant in db/m-5/6Nx mice. In conclusion, we demonstrated that nonconcordant regulation of mitochondrial complexes in db/m-5/6Nx mice involved with glomerular hyperfiltration. The progression and/or severity of nephropathymight be affected through a synergistic effect of mitochondrial dysfunction in hyperglycemia and glomerular hyperfiltration.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
64
3-4
開始ページ
255
終了ページ
261
並び順
255
発行日
2017-08
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Yukie Nakashitaの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3137号
学位記番号
甲栄第246号
学位授与年月日
2018-02-22
学位名
博士(栄養学)
学位授与機関
徳島大学
部局
医学系