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ID 111589
タイトル別表記
Ketone Bodies Elevation in Placenta, Umbilical Cord, Newborn and Mother
著者
Muneta, Tetsuo Muneta Maternity Clinic
Kawaguchi, Eri Muneta Maternity Clinic
Nagai, Yasushi Nagai Mothers Hospital
Matsumoto, Momoyo Nagai Mothers Hospital
Ebe, Koji Takao Hospital
Watanabe, Hiroko Osaka University
板東, 浩 Tokushima University|Kitajima Taoka Hospital KAKEN研究者をさがす
キーワード
ketone bodies
3-hydroxybutyric acid (β-hydroxybutyric acid)
placenta
umbilical cord
newborn
資料タイプ
学術雑誌論文
抄録
Background: Low carbohydrate diets (LCD) have been recently prevalent in the medical and health field, especially in diabetes mellitus. We have applied LCD on thousands of patients with metabolic diseases and reported the clinical effect of LCD so far. Through our experience and research concerning LCD, the physiological role of glucose and ketone bodies during the pre- and post-partum period was investigated in this study.
Subjects and methods: Subjects were 60 normal pregnant woman who had a normal delivery in full-term, without an abnormal glucose intolerance. Methods included the measurement of the value of ketone bodies in the umbilical cord blood, placental tissue fluid and maternal blood, associated with the value of blood glucose. As ketone bodies, the value of 3-hydroxybutyric acid (3-OHBA, beta-hydroxybutyric acid) was measured. 3-OHBA and glucose values were measured by the electrode method using Precision Exceed Kit (Abbott) and the conventional enzymatic cycling method, with comparison investigation of the data from two kits.
Results: The average 3-OHBA levels were as follows: 2,235.0 μmol/L in the placenta, 779.2 μmol/L in the umbilical cord blood, in which the former is significantly higher than the latter (p < 0.001), 240.4μmol/L in the newborn after four days, and 366.7μmol/L after 30 days. The standard 3-OHBA level in a healthy man is less than 85 μmol/L. Glucose levels in the umbilical cord and placenta were 78.6 mg/dL vs 74.9 mg/dL, with no significant difference, and was the same as that of the pregnant woman. Accuracy management of the two kits revealed a significant correlation (r = 0.94, p < 0.001). 3-OHBA values of the maternal blood and umbilical cord blood were extremely elevated from the standard level, with a mutual significant correlation (r = 0.724, p < 0.001, n = 416).
Conclusion: This clinical study concerning ketone bodies during pre- and post-partum period was investigated, and revealed that 1) a clinically rapid useful kit for ketone bodies had high reliability and validity compared with conventional kit, 2) elevated values of 3-OHBA were shown in the placental tissue fluid, umbilical cord, newborn and maternal blood, 3) 3-OHBA would be a physiologically indispensable element in nutrition metabolism for fetus and newborn at least until 30 days, with further development of investigation for ketone bodies.
掲載誌名
Glycative Stress Research
ISSN
21883610
21883602
出版者
Society for Glycative Stress Research
3
3
開始ページ
133
終了ページ
140
発行日
2016-09-30
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系