アクセス数 : ?
ダウンロード数 : ?
ID 110651
著者
Lu, Guangming Second Department of Internal Medicine, The University of Tokushima School of Medicine
清水, 一郎 Second Department of Internal Medicine, The University of Tokushima School of Medicine
Cui, Xuezhi Second Department of Internal Medicine, The University of Tokushima School of Medicine
イトナガ, ミナ Second Department of Internal Medicine, The University of Tokushima School of Medicine
タマキ, カツヨシ Second Department of Internal Medicine, The University of Tokushima School of Medicine
フクノ, ヒロシ Second Department of Internal Medicine, The University of Tokushima School of Medicine
イノウエ, ヒロシ Second Department of Internal Medicine, The University of Tokushima School of Medicine
本田, 浩仁 Second Department of Internal Medicine, The University of Tokushima School of Medicine
伊東, 進 Second Department of Internal Medicine, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧
キーワード
interferon-α
oxidative stress
lipid peroxidation
hepatic fibrosis
hepatic stellate cell
antioxidant enzyme
資料タイプ
学術雑誌論文
抄録
Oxidative stress has been implicated as a cause of hepatic fibrosis, and hepatic stellate cells (HSCs), which are the most important collagen-producing cell types, have been reported to be activated by lipid peroxidation products. Antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPx) provide a defense system that plays a critical role in protecting the cell from free radical damage, particularly lipid peroxidation. To elucidate the antioxidant activity of interferon-α (IFN-α), the effects of IFN-α on rat hepatocytes undergoing oxidative stress and HSCs in primary culture as well as isolated rat liver mitochondria were examined. IFN-α was observed to dose-dependently increase the immunoreactive protein levels of copper, zinc-and manganese-dependent SOD as well as the enzyme activities of GPx, and decrease the lipid peroxidation product levels and oxidative burst both in stressed hepatocytes and activated HSCs GPx activities, however, were not detected in the latter cells. IFN-α also inhibited HSC activation and lipid peroxidation in liver mitochondria. These findings suggest that IFN-α may enhance biological defense activities against oxidative stress and function as a potent fibrosuppressant by protecting hepatocytes and hepatic stellate cells from lipid peroxidation in vivo.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
49
3-4
開始ページ
172
終了ページ
181
並び順
172
発行日
2002
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系