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ID 119312
タイトル別表記
sPLA2-IIE, a Hair Follicular sPLA2
著者
山本, 圭 Tokyo Metropolitan Institute of Medical Science|Tokushima University|Japan Agency for Medical Research and Development 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Miki, Yoshimi Tokyo Metropolitan Institute of Medical Science
Sato, Hiroyasu Tokyo Metropolitan Institute of Medical Science
Nishito, Yasumasa Tokyo Metropolitan Institute of Medical Science
Gelb, Michael H. University of Washington
Taketomi, Yoshitaka Tokyo Metropolitan Institute of Medical Science
Murakami, Makoto Tokyo Metropolitan Institute of Medical Science|Japan Agency for Medical Research and Development
資料タイプ
学術雑誌論文
抄録
Recent studies using knock-out mice for various secreted phospholipase A2 (sPLA2) isoforms have revealed their non-redundant roles in diverse biological events. In the skin, group IIF sPLA2 (sPLA2-IIF), an “epidermal sPLA2” expressed in the suprabasal keratinocytes, plays a fundamental role in epidermal-hyperplasic diseases such as psoriasis and skin cancer. In this study, we found that group IIE sPLA2 (sPLA2-IIE) was expressed abundantly in hair follicles and to a lesser extent in basal epidermal keratinocytes in mouse skin. Mice lacking sPLA2-IIE exhibited skin abnormalities distinct from those in mice lacking sPLA2-IIF, with perturbation of hair follicle ultrastructure, modest changes in the steady-state expression of a subset of skin genes, and no changes in the features of psoriasis or contact dermatitis. Lipidomics analysis revealed that sPLA2-IIE and -IIF were coupled with distinct lipid pathways in the skin. Overall, two skin sPLA2s, hair follicular sPLA2-IIE and epidermal sPLA2-IIF, play non-redundant roles in distinct compartments of mouse skin, underscoring the functional diversity of multiple sPLA2s in the coordinated regulation of skin homeostasis and diseases.
掲載誌名
Journal of Biological Chemistry
ISSN
00219258
1083351X
cat書誌ID
AA1202441X
出版者
American Society for Biochemistry and Molecular Biology|Elsevier
291
30
開始ページ
15602
終了ページ
15613
発行日
2016-05-23
権利情報
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
生物資源系