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ID 83941
著者
ワタナベ, マサナリ Division of Respirology and Rheumatology, Faculty of Medicine, Tottori University
サノ, ヒロユキ Department of Respiratory Medicine and Allegology, School of Medicine
トミタ, カツユキ Department of Respiratory Medicine and Allegology, School of Medicine
ヤマサキ, アキラ Division of Respirology and Rheumatology, Faculty of Medicine, Tottori University
クライ, ジュン Division of Respirology and Rheumatology, Faculty of Medicine, Tottori University
ハセガワ, ヤスユキ Division of Respirology and Rheumatology, Faculty of Medicine, Tottori University
イギシ, タダシ Division of Respirology and Rheumatology, Faculty of Medicine, Tottori University
オカザキ, リョウタ Division of Respirology and Rheumatology, Faculty of Medicine, Tottori University
トオダ, ユウジ Department of Respiratory Medicine and Allegology, School of Medicine
ブリオカ, ナオト Division of Respirology and Rheumatology, Faculty of Medicine, Tottori University
シミズ, エイジ Division of Respirology and Rheumatology, Faculty of Medicine, Tottori University
キーワード
airway responsiveness
asthma
circadian rhythm
gastroesophageal reflux
salivary pH
資料タイプ
学術雑誌論文
抄録
Salivary pH is associated with esophageal acid reflux and neutralization of
esophageal acid. In this study, we assessed the association between nocturnal decline of
salivary pH and airway hyperresponsiveness. Salivary pH was serially assessed in 9 patients
with mild asthma (7 men and 2 women ;mean age 33.3 years ;mean %predicted
FEV1.0 89.4%) and 10 healthy volunteers (6 men and 4 women ; mean age 31.2 years) using
a pH indicator tape. The buffering capacity of saliva was defined as the median effective
dose (ED50) for acidification of saliva with 0.01 N HCl, and airway responsiveness was
defined as the dose of methacholine producing a 35% fall in Grs (PD35-Grs). There was a
significant correlation between the values obtained from the pH indicator tape and those
obtained from the electrometric pH meter. Using the indicator tape for sequential monitoring,
we observed a nocturnal fall (pH) in salivary pH in all subjects. A significant correlation
was found between airway hyperresponsiveness (PD35-Grs) and eitherpH or ED50
in mildly asthmatic patients. Vagal reflux dysfunction might contribute to nocturnal
salivary pH as well as to airway hyperresponsiveness in mild asthmatics.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
57
3-4
開始ページ
260
終了ページ
269
並び順
260
発行日
2010-08
備考
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
フルテキストファイル
言語
eng