アクセス数 : ?
ダウンロード数 : ?
ID 110148
著者
ハマダ, ジュンイチ Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School|Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
ショウダ, カツトシ Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School|Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
増田, 清士 Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School KAKEN研究者をさがす
フジタ, ユウジ Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School|Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
成戸, 卓也 Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School KAKEN研究者をさがす
コウモト, トモヒロ Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School|Student Lab, Tokushima University Faculty of Medicine
ミヤカミ, ユウコ Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School|Student Lab, Tokushima University Faculty of Medicine
ワタナベ, ミキ Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School|Student Lab, Tokushima University Faculty of Medicine
クドウ, ヤスセイ Department of Oral Molecular Pathology, Institute of Biomedical Sciences, Tokushima University Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
フジワラ, ヒトシ Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
イチカワ, ダイスケ Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
オオツジ, エイゴ Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
井本, 逸勢 Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
T-cell intracellular antigen-1
isoform
oncogene
RNA-binding protein
esophageal squamous cell carcinoma
資料タイプ
学術雑誌論文
抄録
T-cell intracellular antigen-1 (TIA1) is an RNA-binding protein involved in many regulatory aspects of mRNA metabolism. Here, we report previously unknown tumor-promoting activity of TIA1, which seems to be associated with its isoform-specific molecular distribution and regulation of a set of cancer-related transcripts, in esophageal squamous cell carcinoma (ESCC). Immunohistochemical overexpression of TIA1 ectopically localized in the cytoplasm of tumor cells was an independent prognosticator for worse overall survival in a cohort of 143 ESCC patients. Knockdown of TIA1 inhibited proliferation of ESCC cells. By exogenously introducing each of two major isoforms, TIA1a and TIA1b, only TIA1a, which was localized to both the nucleus and cytoplasm, promoted anchorage-dependent and anchorage-independent ESCC cell proliferation. Ribonucleoprotein immunoprecipitation, followed by microarray analysis or massive-parallel sequencing, identified a set of TIA1-binding mRNAs, including SKP2 and CCNA2. TIA1 increased SKP2 and CCNA2 protein levels through the suppression of mRNA decay and translational induction, respectively. Our findings uncover a novel oncogenic function of TIA1 in esophageal tumorigenesis, and implicate its use as a marker for prognostic evaluation and as a therapeutic target in ESCC.
掲載誌名
Oncotarget
ISSN
19492553
7
13
開始ページ
17111
終了ページ
17128
並び順
17111
発行日
2016-03-06
備考
Copyright: © 2016 Masuda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source arecredited.
EDB ID
出典
Oncotarget (2016) Vol.7 No.13 p.17111-17128
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
歯学系