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ID 113592
タイトル別表記
Periostin and cancer
著者
Siriwardena, B.S.M.S. Hiroshima University
Hatano, H. Hiroshima University
Ogawa, I. Hiroshima University
高田, 隆 Hiroshima University
キーワード
Periostin
Invasion
Metastasis
Angiogenesis
Cancer
資料タイプ
学術雑誌論文
抄録
Periostin is a secreted protein that shares a structural homology to the axon guidance protein fasciclin I (FAS1) in insects and was originally named as osteoblast-specific factor-2 (Osf2). Periostin is particularly highly homologus to ßig-h3, which promotes cell adhesion and spreading of fibroblasts. It has recently been reported that Periostin was frequently overexpressed in various types of human cancers. Although the detailed function of Periostin is still unclear, Periostin-integrin interaction through FAS1 domain is thought to be involved in tumor development. In addition, Periostin stimulates metastatic growth by promoting cancer cell survival, invasion and angiogenesis. Therefore, Periostin can be a useful marker to predict the behavior of cancer. This review summarizes the recent understanding of Periostin roles in tumor development and speculates on the usefulness of Periostin as a therapeutic and diagnostic target for cancer.
掲載誌名
Histology and Histopathology
ISSN
16995848
02133911
cat書誌ID
AA10688044
出版者
University of Murcia
22
10
開始ページ
1167
終了ページ
1174
発行日
2007-07-04
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系