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ID 113596
タイトル別表記
Periostin overexpression and oral cancer
著者
Siriwardena, BSMS Hiroshima University|University of Peradeniya
Ogawa, I Hiroshima University
Kitagawa, M Hiroshima University
Kitajima, S Hiroshima University
Hatano, H Hiroshima University
Tilakaratne, WM University of Peradeniya
宮内, 睦美 Hiroshima University
高田, 隆 Hiroshima University
キーワード
periostin
oral cancer
invasion
metastasis
angiogenesis
資料タイプ
学術雑誌論文
抄録
Oral squamous-cell carcinoma (OSCC) is one of the most common types of human cancer. Typically OSCC cells show persistent invasion that frequently leads to local recurrence and distant lymphatic metastasis. We previously identified Periostin as the gene demonstrating the highest fold change expression in the invasive clone by comparing the transcriptional profile of parent OSCC cell line and a highly invasive clone. Here, we demonstrated that Periostin overexpression enhanced invasiveness in oral cancer cell lines. To know the role of Periostin in invasion, angiogenesis and metastasis in OSCC cases, we first examined the expression of Periostin mRNA in 31 OSCC cases by RT–PCR and Periostin protein in 74 OSCC cases by immunohistochemistry. Then, we compared the Periostin expression with invasion pattern, metastasis and blood vessel density. Periostin mRNA and protein overexpression were frequently found in OSCC cases and Periostin expression was well correlated with the invasion pattern and metastasis. Moreover, blood vessel density of Periostin-positive cases was higher than those of Periostin-negative cases. Interestingly, recombinant Periostin enhanced capillary formation in vitro in a concentration-dependant manner. In summary, these findings suggest that Periostin may promote invasion and angiogenesis in OSCC, and that Periostin can be a strong marker for prediction of metastasis in oral cancer patients.
掲載誌名
British Journal of Cancer
ISSN
00070920
15321827
cat書誌ID
AA00574355
出版者
Springer Nature
95
10
開始ページ
1396
終了ページ
1403
発行日
2006-10-24
権利情報
This work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License(http://creativecommons.org/licenses/by-nc-sa/3.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系