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ID 115652
著者
Otsuka, Ikuo Kobe University|RIKEN
Akiyama, Masato RIKEN|Kyushu University
Shirakawa, Osamu Kindai University
Okazaki, Satoshi Kobe University
Momozawa, Yukihide RIKEN
Kamatani, Yoichiro RIKEN|The University of Tokyo
Izumi, Takeshi Health Sciences University of Hokkaido
Takahashi, Motonori Kobe University
Boku, Shuken Kobe University
Sora, Ichiro Kobe University
Yamamoto, Ken Kurume University
Ueno, Yasuhiro Kobe University
Toda, Tatsushi University of Tokyo
Kubo, Michiaki RIKEN
Hishimoto, Akitoyo Kobe University
資料タイプ
学術雑誌論文
抄録
Suicide is a significant public health problem worldwide, and several Asian countries including Japan have relatively high suicide rates on a world scale. Twin, family, and adoption studies have suggested high heritability for suicide, but genetics lags behind due to difficulty in obtaining samples from individuals who died by suicide, especially in non-European populations. In this study, we carried out genome-wide association studies combining two independent datasets totaling 746 suicides and 14,049 non-suicide controls in the Japanese population. Although we identified no genome-wide significant single-nucleotide polymorphisms (SNPs), we demonstrated significant SNP-based heritability (35–48%; P < 0.001) for completed suicide by genomic restricted maximum-likelihood analysis and a shared genetic risk between two datasets (P best = 2.7 × 10−13) by polygenic risk score analysis. This study is the first genome-wide association study for suicidal behavior in an East Asian population, and our results provided the evidence of polygenic architecture underlying completed suicide.
掲載誌名
Neuropsychopharmacology
ISSN
0893133X
1740634X
cat書誌ID
AA10761483
出版者
American College of Neuropsychopharmacology|Springer Nature
44
12
開始ページ
2119
終了ページ
2124
発行日
2019-09-02
権利情報
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系