| ID | 83939 |
| 著者 |
ナカタニ, ハジメ
Department of Surgery, Kubokawa Hospital, Shimanto-cho
アキモリ, トヨカズ
Department of General Surgery, Hatakenmin Hospital, Sukumo
タケザキ, ユカ
Department of Surgery, Kochi Medical School, Kochi University
ハナザキ, カズヒロ
Department of Surgery, Kochi Medical School, Kochi University
|
| キーワード | esophagus
so-called carcinosarcoma
vascular endothelial growth factor
vascular endothelial growth factor receptor
|
| 資料タイプ |
学術雑誌論文
|
| 抄録 | Human carcinosarcomas of esophagus are uncommon malignant neoplasms that
are composed both carcinomatous and sarcomatous components. We established a novel cell line, HN-Eso-1, from the metastatic esophageal spindle cell carcinoma (so-called carcinosarcoma). In this study, we estimated the vascular endothelial growth factors (VEGFs) and VEGF receptors (VEGFRs). Reverse transcription polymerase chain reaction (RTPCR) studies revealed that VEGF-A,-C,-D and VEGFR-1,-2 were upregulated. Cisplatin reduced the cell viability of HN-Eso-1 cells and VEGF attenuated its effect. These results suggest that expression of VEGF-A, VEGF-C, VEGF-D, VEGFR-1, and VEGFR-2 are involved in the cell’s autocrine system and that VEGF protected these cells from the antitumor agent. |
| 掲載誌名 |
The journal of medical investigation : JMI
|
| ISSN | 13431420
|
| cat書誌ID | AA11166929
|
| 巻 | 57
|
| 号 | 3-4
|
| 開始ページ | 232
|
| 終了ページ | 236
|
| 並び順 | 232
|
| 発行日 | 2010-08
|
| 備考 | The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
|
| フルテキストファイル | |
| 言語 |
eng
|
