ID | 114023 |
タイトル別表記 | Osteocalcin and body fat in type 1 diabetes
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著者 |
髙士, 祐一
Tokushima University
Ishizu, Masashi
Tokushima University
Miyashita, Kazuyuki
Osaka University
Sakamoto, Fumie
Osaka University
Katakami, Naoto
Osaka University
Matsuoka, Taka-aki
Osaka University
Yasuda, Tetsuyuki
Osaka Police Hospital
橋田, 誠一
Tokushima Bunri University
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資料タイプ |
学術雑誌論文
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抄録 | The objective of the present study was to investigate the correlations between serum under-carboxylated osteocalcin (ucOC) or osteocalcin (OC) concentrations and %body fat, serum adiponectin and free-testosterone concentration, muscle strength and dose of exogenous insulin in patients with type 1 diabetes. We recruited 73 Japanese young adult patients with childhood-onset type 1 diabetes. All participants were receiving insulin replacement therapy. The correlations between logarithmic serum ucOC or OC concentrations and each parameter were examined. Serum ucOC and OC concentrations were inversely correlated with% body fat (r = -0.319, P = 0.007; r = -0.321, P = 0.006, respectively). Furthermore, multiple linear regression analyses were performed to determine whether or not serum ucOC or OC concentrations were factors associated with %body fat. Serum ucOC and OC concentrations remained significant factors even after adjusting for gender, HbA1c, body weight-adjusted total daily dose of insulin and duration of diabetes (β = -0.260, P = 0.027; β = -0.254, P = 0.031, respectively). However, serum ucOC and OC concentrations were not correlated with serum adiponectin or free-testosterone concentrations, muscle strength or dose of exogenous insulin. In conclusion, our study demonstrates the inverse correlation between serum ucOC or OC concentrations and body fat in patients with type 1 diabetes.
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掲載誌名 |
PLOS ONE
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ISSN | 19326203
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出版者 | PLOS
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巻 | 14
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号 | 5
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開始ページ | e0216416
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発行日 | 2019-05-03
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権利情報 | © 2019 Takashi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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言語 |
eng
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出版社版
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部局 |
先端酵素学研究所
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