躁うつ病患者(MDI) の体性感覚誘発電位(SEP)

The differences between MDI (Manic-Depressive-Illness) patients and healthy subjects in Somatosensory Evoked Potential (SEP) were studied with 45 MDI subjects (22 males and 23 females) and 60 healthy subjects (30 males and 30 females). SEP were recorded through the two deviations (1 stCH : C3→F3 and 4 thCH : C3→A1+2), together with EEG. The following results were obtained.
1. As compared to healthy subjects, the peak latencies (N 2~N 3) were significantly longer, and interpeak amplitudes were significantly larger in the middle-latency components in MDI, in both sexes. Furthermore, the latencies of short-latency components were significantly longer, but there were no significant differences in long latency components in female MDI. These results suggest that MDI has some dysfunction in the neural pathway from brain stem to the primary somatosensory cortex.
2. As for the differences between SEP recorded in manic and depressive states, there were no significant difference in the peak latencies and interpeak amplitudes. Furthermore, there were little significant differences in SEP, between the patients treated regularly with lithium carbonate or carbamazepine, or not, and between who had the clinical history more than 2 years or not.
3. These results are thought to support the comprehensive classical concept of MDI by the electrophysiological point of view, and to reflect the pathophysiological condition in manic-depressive illness.