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ID 110124
タイトル別表記
食餌性リンは大腸炎モデル動物の病態を悪化させる
著者
杉原, 康平 徳島大学大学院栄養生命科学教育部(人間栄養科学専攻)
Nakao, Mari Tokushima University
Abuduli, Maerjianghan Tokushima University
伊美, 友紀子 Tokushima University
Oda, Naoko Tokushima University
キーワード
Dietary Pi
DSS-induced colitis
proinflammatory cytokine
NF-κB
ROS
資料タイプ
学位論文
抄録
The recent widespread consumption of Western diets and food additives worldwide is associated with excessive inorganic phosphate intake. However, researchers have known little about the impact of dietary phosphate intake on the development of inflammatory bowel disease to date. In this study, we investigated the effects of dietary phosphate on intestinal inflammation in experimental colitis. Sprague-Dawley rats were fed different phosphate diets (0.5%, 1.0% and 1.5% phosphate) with or without dextran sulfate sodium. For in vitro study, the effects of phosphate on proinflammatory cytokine induction and reactive oxygen species production in RAW264.7 macrophage were examined. Dietary phosphate exacerbated intestinal inflammation in experimental colitis in a dose-dependent manner, as assessed by the clinical disease activity score, colon length, and histology. Furthermore, the high phosphate diet increased myeloperoxidase activity and proinflammatory cytokine mRNA expression through the activation of nuclear factor κB in the inflamed colon. In addition, high phosphate loading in RAW264.7 cells directly enhanced reactive oxygen species production and proinflammatory cytokine gene expression. Our results demonstrated that the high phosphate diet exacerbated intestinal inflammation in experimental colitis. These findings have important therapeutic implications for inflammatory bowel disease patients.
掲載誌名
Journal of Clinical Biochemistry and Nutrition
ISSN
18805086
09120009
cat書誌ID
AA10710201
AA12091064
出版者
SOCIETY FOR FREE RADICAL RESEARCH JAPAN
61
2
開始ページ
91
終了ページ
99
発行日
2017-09-01
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨:LID201705191027.pdf
論文本文:k3010_fulltext.pdf
著者の申請により要約(2017-05-19公開)に替えて論文全文を公開(2018-02-15)
本論文は, 著者Kohei Sugiharaの学位論文として提出され, 学位審査・授与の対象となっている。
権利情報
© 2017 Society for Free Radical Research Japan
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3090号
学位記番号
甲栄第242号
学位授与年月日
2017-03-23
学位名
博士(栄養学)
学位授与機関
徳島大学
部局
医学系