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ID 106136
タイトル別表記
健常人におけるA1型とA2型のボツリヌス神経毒素の電気生理学的検査による比較
著者
向井, 洋平 徳島大学大学院医科学教育部(医学専攻)
島谷, 佳光 University of Tokushima
Asanuma, Kotaro University of Tokushima
Sakamoto, Takashi National Center Hospital of Neurology and Psychiatry
Kohda, Tomoko Osaka Prefecture University
Kozaki, Shunji Osaka Prefecture University
キーワード
Botulinum neurotoxin
A2NTX
EDB test
CMAP
資料タイプ
学位論文
抄録
Botulinum neurotoxin type A1 (BoNTs/A1) and type B (BoNT/B) have been used for treating hyperactive muscle contractions. In the present study, we compared the effect of botulinum neurotoxin subtype A2 (6.5 mouse LD50 units A2 neurotoxin, A2NTX) and onabotulinumtoxinA (10 mouse LD50 units BoNT/A1 product) by measuring the compound muscle action potentials (CMAPs) before and after administration.
In total, 8 healthy subjects were examined in the present study. A2NTX was injected into the extensor digitorum brevis (EDB) muscle, followed by onabotulinumtoxinA injection into the contralateral EDB muscle after 16 weeks. The CMAP amplitudes from the EDB, abductor hallucis (AH), and abductor digiti minimi pedis (ADM) muscles were measured after each BoNT injection on days 1, 3, 7, 14, 28, 56, 84, and 112 to assess the effect of the toxin. On day 14, both A2NTX and onabotulinumtoxinA produced an approximately 70% decline in EDB CMAP amplitude compared to the baseline values; significant reduction of the CMAP continued through day 112. The CMAP amplitudes from neighboring muscles (AH and ADM) remained intact throughout the study period, except for a slight but significant drop at day 28 after onabotulinumtoxinA injection compared to A2NTX. The current findings indicate that small doses (6.5 units and 10 units) of A2NTX and onabotulinumtoxinA have at least comparable onset and duration of action, although similar clinical effects were obtained with lower dose using A2NTX.
掲載誌名
Toxicon
ISSN
00410101
cat書誌ID
AA00864479
AA11540151
出版者
Elsevier
81
開始ページ
32
終了ページ
36
発行日
2014-02-01
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201405131007.pdf
論文本文 : LID201501221003.pdf
本論文は, 著者Yohei Mukaiの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2743号
学位記番号
甲医第1204号
学位授与年月日
2014-03-19
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系