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ID 114895
著者
Nagai, Kazue Gunma University
Hayashi, Kunihiko Gunma University
Katanoda, Kota National Cancer Center
Iso, Hiroyasu Osaka University
Kiyohara, Yutaka Kyushu University
Wakatsuki, Akihiko Aichi Medical University
Kubota, Toshiro Tokyo Medical and Dental University
Mizunuma, Hideki Hirosaki University
資料タイプ
学術雑誌論文
抄録
Objective: To classify diseases based on age at peak incidence to identify risk factors for later disease in women’s life course.
Design: A cross-sectional baseline survey of participants in the Japan Nurses’ Health Study.
Setting: A nationwide prospective cohort study on the health of Japanese nurses. The baseline survey was conducted between 2001 and 2007 (n=49 927).
Main outcome measures: Age at peak incidence for 20 diseases from a survey of Japanese women was estimated using the Kaplan-Meier method with the Kernel smoothing technique. The incidence rate and peak incidence for diseases whose peak incidence occurred before the age of 45 years or before the perimenopausal period were selected as early-onset diseases. The OR and 95% CI were estimated to examine the risk of comorbidity between early-onset and other diseases.
Results: Four early-onset diseases (endometriosis, anaemia, migraine headache and uterine myoma) were significantly correlated with one another. Late-onset diseases significantly associated (OR>2) with early-onset diseases included comorbid endometriosis with ovarian
cancer (3.65 (2.16 to 6.19)), endometrial cancer (2.40 (1.14 to 5.04)) and cerebral infarction (2.10 (1.15 to 3.85)); comorbid anaemia with gastric cancer (3.69 (2.68 to 5.08)); comorbid migraine with transient ischaemic attack (3.06 (2.29 to 4.09)), osteoporosis (2.11 (1.71 to 2.62)), cerebral infarction (2.04 (1.26 to 3.30)) and angina pectoris (2.00 (1.49 to 2.67)); and comorbid uterine myoma with colorectal cancer (2.31 (1.48 to 3.61)).
Conclusions: While there were significant associations between four early-onset diseases, women with a history of one or more of the early-onset diseases had a higher risk of other diseases later in their life course. Understanding the history of early-onset diseases in women may help reduce the subsequent risk of chronic diseases in later life.
掲載誌名
BMJ Open
ISSN
20446055
出版者
BMJ Publishing Group
5
3
開始ページ
e006360
発行日
2015-03-11
権利情報
This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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言語
eng
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出版社版
部局
医学系