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ID 111693
タイトル別表記
RET MUTATIONS IN PHEOCHROMOCYTOMAS
著者
Kimura, Takehiko The University of Tokushima
田中, 知里 The University of Tokushima KAKEN研究者をさがす
Moritani, Maki The University of Tokushima
Iwahana, Hiroyuki The University of Tokushima
キーワード
RET proto-oncogene
Mutation
Codon 768
Exon 13
Pheochromocytoma
資料タイプ
学術雑誌論文
抄録
Sixteen sporadic pheochromocytomas, 3 pheochromocytomas in neurofibromatosis 1, and 4 pheochromocytomas in multiple endocrine neoplasia (MEN) 2A or 2B were screened for mutations at codon 768 of the RET proto-oncogene by AluI digestion of polymerase chain reaction (PCR) products and mutations in exon 13 by PCR-single strand conformation polymorphism (SSCP) analysis. Although mutations at codon 768 (GAG→GAC; Glu→Asp) of the RET proto-oncogene were recently reported to be found in 40% of sporadic medullary thyroid carcinomas (MTCs), the absence of missense mutations at codon 768 was confirmed both with PCR-restriction fragment length polymorphism (RFLP) and PCR-SSCP analysis in all examined cases of pheochromocytomas. These results suggest that mutations at codon 768 of the RET proto-oncogene do not represent a frequent mechanism of tumorigenesis for both sporadic and hereditary pheochromocytomas.
掲載誌名
Endocrine Journal
ISSN
13484540
09188959
cat書誌ID
AA12020190
AA10901436
出版者
The Japan Endocrine Society
43
1
開始ページ
109
終了ページ
114
発行日
1996
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系
病院
先端酵素学研究所