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ID 113585
タイトル別表記
N-cadherin expression in head and neck cancer
著者
Nguyen, Phuong Thao Hiroshima University
Yoshida, Maki Hiroshima University
鎌田, 伸之 Hiroshima University
Ogawa, Ikuko Hiroshima University
高田, 隆 Hiroshima University
キーワード
N-cadherin
E-cadherin
EMT
Invasion
Head and neck squamous cell carcinoma
資料タイプ
学術雑誌論文
抄録
The loss of E-cadherin and the gain of N-cadherin expression are known as “cadherin switching”. Cadherin switching is a major hallmark of epithelial-mesenchymal transition (EMT). EMT is a crucial process in cancer progression, providing cancer cells with the ability to escape from the primary focus, to invade stromal tissues and to migrate to distant regions. Although down-regulation of E-cadherin is well known in various cancers, there are a few studies on N-cadherin expression in cancer. Here, therefore, we investigated whether N-cadherin expression was associated with the progression of head and neck squamous cell carcinoma (HNSCC). First, we examined the expression of N-cadherin by immunohistochemistry and its correlation with clinico-pathological findings. High expression of N-cadherin was observed in 52 of 80 HNSCC cases and was significantly correlated with malignant behaviors. Next, we examined the correlation between N-cadherin and E-cadherin. Cadherin switching (high expression of N-cadherin and low expression of E-cadherin) was found in 30 of 80 HNSCC cases and was well correlated with histological differentiation, pattern of invasion and lymph node metastasis in HNSCC cases. Moreover, we examined the expression of N-cadherin and E-cadherin by RT-PCR in 16 HNSCC cell lines to confirm the immunohistochemical findings. N-cadherin expression was observed in 7 of 16 HNSCC cells, and cadherin switching was observed in 2 HNSCC cells. Interestingly, HNSCC cells with cadherin switching have EMT features. In conclusion, we suggest that i) N-cadherin may play an important role in malignant behaviors of HNSCC, and ii) cadherin switching might be considered as a discrete critical event in EMT and metastatic potential of HNSCC.
掲載誌名
Histology and Histopathology
ISSN
16995848
02133911
cat書誌ID
AA10688044
出版者
University of Murcia
26
2
開始ページ
147
終了ページ
156
発行日
2010-12-13
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系