Ebe, Koji Takao Hospital|Japan Low Carbohydrate Diet Promotion Association
Muneta, Tetsuo Japan Low Carbohydrate Diet Promotion Association|Muneta Maternity Clinic
Bando, Masahiro Tokushima University
Yonei, Yoshikazu Doshisha University
Type 2 diabetes mellitus (T2DM)
Morbus value (M value)
Homeostasis model assessment of insulin resistance (HOMA-R)
Homeostasis model assessment of β cell function (HOMA-β)
Daily profile of blood glucose
Immunoreactive insulin (IRI)
Background: Low Carbohydrate Diet (LCD) and Calorie Restriction (CR) have been on discussion for years. Authors have continued diabetic research about LCD, CR, Morbus (M) value and insulin secretion. In this study, homeostasis model assessment (HOMA) was investigated.
Subjects and Methods: Subjects enrolled were 52 patients with type 2 diabetes mellitus (T2DM) (average 62.3 years). Methods included the measurement of fasting glucose and immunoreactive insulin (IRI), daily profile of blood glucose and M value.
Results:The obtained data were as follows: average HbA1c 8.0%, average glucose of daily profile 222mg/dL. Median data were M value 151, HOMA-R 1.07, HOMA-β 11.1. Divided into 4 groups due to M value, the levels of HOMA-R and HOMA-β in each group were 0.68, 1.08, 1.64, 1.38 and 16.9, 16.3, 10.2, 5.3, respectively. Significant correlation were observed between M value and HOMA-R (p<0.01), and between M value and HOMA-β (p<0.01).
Discussion and Conclusion: As M value increases, HOMA-R increases and HOMA-β decreases. These findings suggested that diabetic patients would have insulin resistance and decreased β cell function correlated to the severity of diabetes, and that obtained results would become the basal data in this field, expecting the further development in the future research.
POJ Clinical Case Reports
© 2018 Koji Ebe, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
pojccr_1_1_004.pdf 321 KB