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ID 106131
タイトル別表記
日本人パーキンソン病患者における両側視床下核深部脳刺激後の神経心理学的および精神医学的評価
Mental changes in PD with STN-DBS
著者
青野, 成孝 徳島大学大学院医学研究科(医学専攻)
伊賀, 淳一 The University of Tokushima KAKEN研究者をさがす
上野, 修一 Ehime University
Agawa, Masahito Naruto Health Insurance Hospital
Tsuda, Toshio Naruto Health Insurance Hospital
大森, 哲郎 The University of Tokushima KAKEN研究者をさがす
キーワード
Anxiety
Cognitive function
Deep brain stimulation
Parkinson’s disease
Subthalamic nucleus
資料タイプ
学位論文
抄録
The physical benefits of subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s disease(PD) patients are well documented, but the mental benefits are uncertain, particularly in Japanese patients. This study evaluated the clinical and neuropsychological characteristics before and after STN-DBS surgery in Japanese PD patients. PD patients (n=13, age 67.0 ± 7.8 years) were evaluated pre-surgery (baseline) and at one and six months post-surgery by two trained psychiatrists. The motor symptoms were assessed by the Unified Parkinson’s Disease Rating Scale (UPDRS) motor score. The neuropsychological and psychiatric tests performed were the Mini-Mental State Examination, the Wisconsin Card Sorting Test (WCST), the verbal fluency test (VFT), the Hamilton Depression Rating Scale and the Hamilton Anxiety Rating Scale (HAM-A). The UPDRS motor score (p<0.001) and HAM-A score (p=0.004) showed significant improvement at one month post-surgery, but a significant decline was observed in the WCST total error (p=0.005) and the semantic VFT score (p<0.001). The phonetic VFT also showed a substantial decline (p=0.015) at one month post-surgery. At six months post-surgery, the improvement in the UPDRS motor score was maintained, and the scores on the neuropsychological and psychiatric tests had returned to baseline. Although bilateral STN-DBS did not appear to have long-term effects on neuropsychological and psychiatric outcomes, the microlesion effects associated with STN-DBS appear to increase the risk of transient cognitive and psychiatric complications. These complications should be monitored by careful observation of neurological and psychiatric symptoms.
掲載誌名
Journal of Clinical Neuroscience
ISSN
09675868
cat書誌ID
AA10958444
出版者
Elsevier
21
9
開始ページ
1595
終了ページ
1598
発行日
2014-04-30
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201405131002.pdf
論文本文 : LID201501221002.pdf
本論文は, 著者Michitaka Aonoの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2738号
学位記番号
甲医第1199号
学位授与年月日
2014-03-19
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系