Kato, Yoshikane Kanaiso Hospital
Fujikawa, Tomomi Kanaiso Hospital
Narutaki, Miyuki Kanaiso Hospital
Yamamoto, Masami Kanaiso Hospital
Kakutani, Hideki Kanaiso Hospital
Shirai, Yujiro Kanaiso Hospital
Ishikura, Kazuyo Kanaiso Hospital
Kusunoki, Kazuhiro Kanaiso Hospital
Tanaka, Saeri Kanaiso Hospital
Kawata, Takafumi Kanaiso Hospital
Kanazawa, Setsuko Kanaiso Hospital
Matsuzaki, Sayuri Kanaiso Hospital
Bando, Masahiro Tokushima University
Waka, Shinnichi Kanaiso Hospital
Diabetic peripheral neuropathy
Nerve conduction studies
Sural nerve conduction velocity
Sural nerve action potential
Background: Diabetic peripheral neuropathy (DPN) has been prevalent and discussed, and nerve conduction studies (NCS) has been continued. We have checked NCS using recently introduced useful DPN-Check device.
Subjects and Methods: The subjects were 66 patients (pts) classified into 4 groups according to existence of diabetes mellitus (DM) and hemodialysis (HD); Group1: DM (+), HD (+) in 15 pts, group 2: DM (-), HD (+) in 15 pts, group 3: DM (+), HD (-) in 20 pts, group 4: 16 healthy controls. Methods included measurements of sural nerve conduction velocity (SNCV) and sural nerve action potential (SNAP) using HDN-1000.
Results: Average age in each group was 64.4 years to 72.6 years. SNCV value of 4 group in average was 37.1 m/sec, 46.3 m/sec, 49.3 m/sec, 53.2 m/sec, respectively, and value of group 1 was significantly lower than those of group 2,3,4 (p<0.01). Similarly, average SNAP was 4.1 μV, 8.7 μV, 8.0 μV, 21.6 μV, respectively, and group 1,2,3 were significantly lower than group 4 (p<0.01). There was significant correlation between SNCV and SNAP in all subjects (p<0.01). Significant correlations were shown between DM duration and SNCV, and DM duration and SNAP (p<0.01).
Discussion and Conclusion: SNCV and SNAP were measured successfully and easily by HDN-1000, indicating clinical availability. Obtained data suggested that 1) SNCV is not significantly decreased due to only uremic neuropathy, 2) SNCV is significantly decreased in patients with both HD and DM, 3) SNAP is significantly decreased in patents with DM for years and 4) SNAP would be remarkably decreased when HD is in addition to DM. These results would become the basal data of future NCS for DM and HD.
Journal of General Practice
© 2017 Kato Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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