アクセス数 : ?
ダウンロード数 : ?
ID 113802
著者
板東, 浩 Tokushima University|Japan Low Carbohydrate Diet Promotion Association KAKEN研究者をさがす
Kato, Yoshikane Kanaiso Hospital
Kanazawa, Setsuko Kanaiso Hospital
Tanaka, Mayumi Kanaiso Hospital
Sueki, Etsuko Kanaiso Hospital
Kanagawa, Hiroe Kanaiso Hospital
Kawata, Takafumi Kanaiso Hospital
Kawahito, Atsuko Kanaiso Hospital
Aihara, Aya Kanaiso Hospital
キーワード
Type 1 diabetes mellitus (T1DM)
Anti-IA-2 antibody
Anti-GAD antibody
HLA-DR type
資料タイプ
学術雑誌論文
抄録
Subjects: Cases are two patients with type 1 diabetes mellitus (T1DM), with the characteristic relationship and onset situation. Case 1 is 46-year-old daughter and case 2 is 69-year-old mother. They have been living apart and they rarely meet together. Twenty-two months after the onset of T1DM case 1, case 2 also developed T1DM. They did not notice clinical manifestation of upper respiratory infection, or they did not have any stressful matters before the onset of T1DM.
Results: Their data in case 1 vs 2 were as follows: BMI 21.3 vs 19.8, HbA1c 10.3% vs 9.8%, anti-IA-2 antibody (IA-2 Ab) 2.1 vs 6.0 (<0.4), anti-GAD antibody (GAD Ab) 24 vs 10000 (<1.5), HLA-DR type DR9 / DR13 vs DR4/DR13.
Discussion and conclusion: These 2 cases have characteristic mode for the onset of T1DM. In Japanese race, DR4 and DR9 have rather high sensitivity for T1DM, DR15 (DR2) has resistance for T1DM and DR13 has unremarkable influence. From these, HLA-DR type would be possible involved in the onset of T1DM, and further investigation would be expected.
掲載誌名
International Journal of Endocrinology Research
出版者
Innovationinfo
1
1
開始ページ
1
終了ページ
3
発行日
2018-11-29
権利情報
© 2018 Bando H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License(https://creativecommons.org/licenses/by-nc-sa/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系