ID 110811
著者
ナカノ, タクロウ Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima Graduate School
新家, 利一 Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima Graduate School
勢井, 雅子 Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima Graduate School
佐藤, 陽一 Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
梅野, 真由美 Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima Graduate School|Major in Laboratory Science, School of Health Sciences ,The University of Tokushima
サカモト, コズエ Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima Graduate School
野村, 以徂子 Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima Graduate School
中堀, 豊 Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima Graduate School
キーワード
UCP-1
A-3826G polymorphism
Japanese
young male
obesity
資料タイプ
学術雑誌論文
抄録
UCP-1 is suggested to have important roles for thermogenesis and energy expenditure. To elucidate whether the A-3826G polymorphism that is located in the 5’ flanking region of the UCP-1 gene has roles in healthy young people, the polymorphism was genotyped among 251 young Japanese men whose mean age is 22.7 years old. We analyzed relationship between the A-3826G polymorphism and body mass index (BMI) or six biochemical parameters, serum concentration of total cholesterol (TC), high density lipoprotein (HDL) cholesterol, triglyceride (TG), asparatate aminotransferase (AST), alanine aminotransferase (ALT), fasting plasma glucose. The genotype frequencies were observed at the frequencies of 24.3% for AA, 48.2% for AG and 27.5% for GG, respectively. When BMI and the biochemical parameters were compared by ANOVA among individuals with each genotype, the statistical difference was observed only for BMI (P=0.016). Bonferroni’s test demonstrated that the men with the AG genotype have higher BMI than those with the AA genotype (22.4±2.8 vs. 21.4±2.2)(P=0.04). The individuals with the AG genotype also showed trend to have higher BMI than those with the GG, although the difference was not statistically apparent (22.4±2.8 vs. 21.5±2.3) (P=0.07). Our results indicated that the young healthy Japanese men with the AG heterozygote showed higher BMI than those with other genotypes.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
53
3-4
開始ページ
218
終了ページ
222
並び順
218
発行日
2006-08
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
薬学系