直近一年間の累計
アクセス数 : ?
ダウンロード数 : ?
ID 116337
タイトル別表記
Hassall’s corpuscles induce thymic IFNα expression
著者
Wang, Jianwei Kyoto University
Sekai, Miho Kyoto University
Matsui, Takeshi RIKEN
Fujii, Yosuke Kyoto University
Takeuchi, Osamu Kyoto University
Minato, Nagahiro Kyoto University
Hamazaki, Yoko Kyoto University
キーワード
Hassall’s bodies
cell senescence
type I interferon
mTEC
thymic epithelial cells
資料タイプ
学術雑誌論文
抄録
Hassall’s corpuscles (HCs) are composed of cornifying, terminally differentiated medullary thymic epithelial cells (mTECs) that are developed under the control of Aire. Here, we demonstrated that HC-mTECs show features of cellular senescence and produce inflammatory cytokines and chemokines including CXCL5, thereby recruiting and activating neutrophils to produce IL-23 in the thymic medulla. We further indicated that thymic plasmacytoid dendritic cells (pDCs) expressing IL-23 receptors constitutively produced Ifna, which plays a role in single positive (SP) cell maturation, in an Il23a-dependent manner. Neutrophil depletion with anti-Ly6G antibody injection resulted in a significant decrease of Ifna expression in the thymic pDCs, suggesting that thymic neutrophil activation underlies the Ifna expression in thymic pDCs in steady state conditions. A New Zealand White mouse strain showing HC hyperplasia exhibited greater numbers and activation of thymic neutrophils and pDCs than B6 mice, whereas Aire-deficient B6 mice with defective HC development and SP thymocyte maturation showed significantly compromised numbers and activation of these cells. These results collectively suggested that HC-mTECs with cell-senescence features initiate a unique cell activation cascade including neutrophils and pDCs leading to the constitutive IFNα expression required for SP T-cell maturation in the thymic medulla.
掲載誌名
International Immunology
ISSN
14602377
cat書誌ID
AA12096432
出版者
Oxford University Press|The Japanese Society for Immunology
31
3
開始ページ
127
終了ページ
139
発行日
2018-12-10
権利情報
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
先端酵素学研究所