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ID 114903
タイトル別表記
MIBG Predicts Falls in PD
著者
Murakami, Nagahisa Tokushima University
古川, 貴大 Tokushima University
キーワード
Parkinson's disease
falls
MIBG
prognosis
motor symptom
資料タイプ
学術雑誌論文
抄録
Background: Falls are associated with poor prognosis in patients with Parkinson's disease (PD). Although several factors related to falls were reported in patients with PD, objective predictors of falls are not identified. We aimed to determine whether 123I-meta-iodobenzylguanidine (MIBG) cardiac scintigraphy could be a useful biomarker to predict falls.
Methods: Forty-five patients with PD were enrolled in this study. These subjects were followed up more than 5 years after MIBG scintigraphy and were divided into two groups: one with decreased uptake of MIBG and the other without decreased uptake of MIBG. The cut-off value for the delayed heart-to-mediastinum ratio was 1.8. Kaplan-Meier analysis and a log-rank test were performed to test the predictive power of MIBG cardiac scintigraphy for falls. Univariate analysis was selected because we did not have appropriate data for adjustment, such as motor and cognitive assessment.
Results: The group with decreased uptake of MIBG had a significantly higher incidence of falls than that without decreased uptake of MIBG (P = 0.022, log-rank test).
Conclusions: Although the limitations of this study were lack of several key factors including motor and cognitive assessment, MIBG cardiac scintigraphy may be used to predict falls in patients with PD.
掲載誌名
Frontiers in Neurology
ISSN
16642295
出版者
Frontiers Media S.A.
10
開始ページ
376
発行日
2019-04-12
権利情報
© 2019 Murakami, Sako, Haji, Furukawa, Otomi, Otsuka, Izumi, Harada and Kaji. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)(https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
医学系