ID 110668
著者
Parajuli, Prahlad Third Department of Internal Medicine, University of Tokushima School of Medicine
矢野, 聖二 Third Department of Internal Medicine, University of Tokushima School of Medicine
埴淵, 昌毅 Third Department of Internal Medicine, University of Tokushima School of Medicine KAKEN研究者をさがす
ノキハラ, ヒロシ Third Department of Internal Medicine, University of Tokushima School of Medicine 徳島大学 教育研究者総覧
篠原, 勉 Third Department of Internal Medicine, University of Tokushima School of Medicine
曽根, 三郎 Third Department of Internal Medicine, University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
Macrolide
human lung cancer
metastasis
SCID mice.
資料タイプ
学術雑誌論文
抄録
Recently, the use of macrolides is suggested to be therapeutically effective in prolonging the survival of patients with inoperable non-small cell lung cancer. The purpose of this study was to examine therapeutic effects of a macrolide, clarythromycin (CAM) on the metastastic developments of two different human non-small cell lung cancers (squamous cell lung carcinoma RERF-LC-AI, and adenocarcinoma PC-14) in severe combined immunodeficient (SCID) mice depleted or undepleted of natural killer (NK) cells, respectively. CAM, injected subcutaneously at doses of 5 and 10 mg/kg body weight/day from day 7 to 41 after i.v. inoculation of human lung cancer cells, was not effective in inhibiting their distant organ metastases in SCID mice. CAM at concentrations of less than 10 μg/ml did not have a direct influence on the proliferation of these tumor cells in vitro. Although CAM alone was not effective in augmenting NK activity, it augmented the IL-2-induced killer (LAK) activity against Daudi cells in vitro. These results suggest that CAM alone may not be enough to control the spread of non-small cell lung cancer in the patient with T cell dysfunction.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
44
3-4
開始ページ
205
終了ページ
210
並び順
205
発行日
1998
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院