Furukawa, Koichi Chubu University|Nagoya University
Ohmi, Yuhsuke Chubu University
Ohkawa, Yuki Chubu University
Bhuiyan, Robiul H. Chubu University
Zhang, Pu Chubu University|Nagoya University
Tajima, Orie Chubu University
橋本, 登 Nagoya University|Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Hamamura, Kazunori Aichi-Gakuin University
Furukawa, Keiko Chubu University
enzyme-mediated activation of radical sources
Cancer-associated glycosphingolipids have been used as markers for diagnosis and targets for immunotherapy of malignant tumors. Recent progress in the analysis of their implications in the malignant properties of cancer cells revealed that cancer-associated glycosphingolipids are not only tumor markers, but also functional molecules regulating various signals introduced by membrane microdomains, lipid rafts. In particular, a novel approach, enzyme-mediated activation of radical sources combined with mass spectrometry, has enabled us to clarify the mechanisms by which cancer-associated glycosphingolipids regulate cell signals based on the interaction with membrane molecules and formation of molecular complexes on the cell surface. Novel findings obtained from these approaches are now providing us with insights into the development of new anticancer therapies targeting membrane molecular complexes consisting of cancer-associated glycolipids and their associated membrane molecules. Thus, a new era of cancer-associated glycosphingolipids has now begun.
Japanese Cancer Association|John Wiley & Sons
© 2019 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. (https://creativecommons.org/licenses/by-nc/4.0/)
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