Furukawa, Koichi Chubu University|Nagoya University
Ohmi, Yuhsuke Chubu University
Yesmin, Farhana Chubu University|Nagoya University
Tajima, Orie Chubu University
Kondo, Yuji Nagoya University
Zhang, Pu Chubu University|Nagoya University
橋本, 登 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Ohkawa, Yuki Osaka International Cancer Institute
Bhuiyan, Robiul H. Chubu University
Furukawa, Keiko Chubu University
Acidic glycosphingolipids, i.e., gangliosides, are predominantly and consistently expressed in nervous tissues of vertebrates at high levels. Therefore, they are considered to be involved in the development and function of nervous systems. Recent studies involving genetic engineering of glycosyltransferase genes have revealed novel aspects of the roles of gangliosides in the regulation of nervous tissues. In this review, novel findings regarding ganglioside functions and their modes of action elucidated mainly by studies of gene knockout mice are summarized. In particular, the roles of gangliosides in the regulation of lipid rafts to maintain the integrity of nervous systems are reported with a focus on the roles in the regulation of neuro-inflammation and neurodegeneration via complement systems. In addition, recent advances in studies of congenital neurological disorders due to genetic mutations of ganglioside synthase genes and also in the techniques for the analysis of ganglioside functions are introduced.
International Journal of Molecular Sciences
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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