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ID 111009
タイトル別表記
年齢に応じた血中活性型ビタミンD濃度, 腎Cyp27b1およびCyp24a1発現に対する食餌性リン反応性の変化には腎α-Klotho遺伝子発現が関連する
著者
吉川, 亮平 徳島大学大学院栄養生命科学教育部(人間栄養科学専攻)
山本, 浩範 University of Tokushima|Jin-ai University|University of Fukui KAKEN研究者をさがす
Nakahashi, Otoki University of Tokushima|Tokushima Bunri University
Kagawa, Tomohiro University of Tokushima
Tajiri, Mari University of Tokushima
Nakao, Mari University of Tokushima
Fukuda, Shiori University of Tokushima
新井, 英一 The University of Shizuoka
Iwano, Masayuki University of Fukui
キーワード
α-Klotho
age-related change
vitamin D metabolism
inorganic phosphate
mice
資料タイプ
学位論文
抄録
In this study, we investigated the relationship between age-related changes in renal α-Klotho gene expression, vitamin D metabolism and the responsiveness of dietary phosphate in 1, 2 and 13 month-old mice fed a high phosphate (phosphate 1.2%) diet or low phosphate (phosphate 0.02%) diet for 5 days. We found that 1,25-dihydroxyvitamin D levels in plasma were significantly lower in the high phosphate group than the low phosphate group for 1 and 2 month-old mice, but not 13 month-old mice. In addition, in the high phosphate group plasma 1,25-dihydroxyvitamin D levels were decreased in 2 month-old mice relative to 1 month-old mice, but 13 month-old mice had higher levels than 2 month-old mice. In fact, plasma 1,25-dihydroxyvitamin D levels showed a significant correlation with vitamin D metabolism gene Cyp27b1 and Cyp24a1 mRNA expression in the high phosphate group. Interestingly, renal α-Klotho mRNA and protein levels were significant change with age. Furthermore, α-Klotho mRNA expression showed a significant negative correlation with plasma 1,25-dihydroxyvitamin D levels in the high phosphate group. Our results suggest that age-related alterations in renal α-Klotho expression could affect the responsiveness of dietary phosphate to vitamin D metabolism.
掲載誌名
Journal of Clinical Biochemistry and Nutrition
ISSN
18805086
09120009
cat書誌ID
AA10710201
AA12091064
出版者
SOCIETY FOR FREE RADICAL RESEARCH JAPAN
62
1
開始ページ
68
終了ページ
74
発行日
2018-01-01
備考
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Ryouhei Yoshikawaの学位論文として提出され, 学位審査・授与の対象となっている。
権利情報
© 2018 Society for Free Radical Research Japan
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3119号
学位記番号
甲栄第245号
学位授与年月日
2017-10-26
学位名
博士(栄養学)
学位授与機関
徳島大学
部局
医学系