ID | 114554 |
タイトル別表記 | Alcohol Intake and Serum Lipids–Genetic Modification
|
著者 |
Sasakabe, Tae
Nagoya University
Wakai, Kenji
Nagoya University
Kawai, Sayo
Nagoya University
Hishida, Asahi
Nagoya University
Naito, Mariko
Nagoya University
Suzuki, Sadao
Nagoya City University
Nindita, Yora
Kagoshima University|Diponegoro University
Kita, Yoshikuni
Tsuruga Nursing University
Hara, Megumi
Saga University
Kuriyama, Nagato
Kyoto Prefectural University of Medicine
Hirata, Akie
Kyushu University
Mikami, Haruo
Chiba Cancer Center
Oze, Isao
Aichi Cancer Center
Kubo, Michiaki
RIKEN
Tanaka, Hideo
Aichi Cancer Center|Nagoya University
Hamajima, Nobuyuki
Nagoya University
|
キーワード | ALDH2
ADH1B
alcohol intake
lipid profile
|
資料タイプ |
学術雑誌論文
|
抄録 | Background: Although beneficial associations have been reported between moderate alcohol intake and the serum lipid profile, it is unclear whether polymorphisms in alcohol-metabolizing enzymes can modify these associations. Here, we assessed the effects of ADH1B His48Arg (rs1229984), ALDH2 Glu504Lys (rs671), and their combination on these associations. Furthermore, we examined if the findings for ALDH2 could be replicated.
Methods: We categorized 889 male participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study into two groups based on presence or absence of minor allele(s) or four groups based on genotype combinations. We performed regression analyses of serum lipid concentrations on alcohol intake, with multivariable adjustment. The replication study was conducted among 2,562 men in the Shizuoka part of the J-MICC Study. Results: The ALDH2 Glu/Lys or Lys/Lys groups showed significant decreases in serum low-density lipoprotein (LDL) cholesterol with increasing alcohol consumption; the coefficient per intake increase of 10 g/day was −2.49 mg/dL (95% confidence interval [CI], −3.85 to −1.13), and a significant interaction with the polymorphism was confirmed (P for interaction = 0.006). This inverse correlation was more evident among the ADH1B His/His + ALDH2 Glu/Lys or Lys/Lys groups (−3.24 mg/dL, 95% CI, −5.03 to −1.45). Serum triglycerides were positively associated with alcohol consumption in the ADH1B His/His group (P for interaction = 0.020). The stronger association between serum LDL cholesterol and alcohol consumption in the ALDH2 Glu/Lys or Lys/Lys groups was replicated. Conclusions: The ALDH2 Glu504Lys polymorphism can modify the association between alcohol intake and serum LDL cholesterol in Japanese men. |
掲載誌名 |
Journal of Epidemiology
|
ISSN | 13499092
09175040
|
cat書誌ID | AA10952696
|
出版者 | Japan Epidemiological Association
|
巻 | 28
|
号 | 4
|
開始ページ | 185
|
終了ページ | 193
|
発行日 | 2017-11-25
|
権利情報 | © 2017 Tae Sasakabe et al. This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. (https://creativecommons.org/licenses/by/4.0/)
|
EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
|
著者版フラグ |
出版社版
|
部局 |
医学系
|