ID | 115486 |
著者 |
Koyama, Teruhide
Kyoto Prefectural University of Medicine
Kuriyama, Nagato
Kyoto Prefectural University of Medicine
Ozaki, Etsuko
Kyoto Prefectural University of Medicine
Matsui, Daisuke
Kyoto Prefectural University of Medicine
Watanabe, Isao
Kyoto Prefectural University of Medicine
Takeshita, Wakiko
Kyoto Prefectural University of Medicine
Iwai, Komei
Kyoto Prefectural University of Medicine
Watanabe, Yoshiyuki
Kyoto Prefectural University of Medicine
Nakatochi, Masahiro
Nagoya University
Shimanoe, Chisato
Saga University
Tanaka, Keitaro
Saga University
Oze, Isao
Aichi Cancer Center Research Institute
Ito, Hidemi
Aichi Cancer Center Research Institute
Ibusuki, Rie
Kagoshima University
Shimoshikiryo, Ippei
Kagoshima University
Takashima, Naoyuki
Shiga University
Kadota, Aya
Shiga University
Kawai, Sayo
Nagoya University
Sasakabe, Tae
Nagoya University
Okada, Rieko
Nagoya University
Hishida, Asahi
Nagoya University
Naito, Mariko
Nagoya University
Kuriki, Kiyonori
University of Shizuoka
Endoh, Kaori
University of Shizuoka
Furusyo, Norihiro
Kyushu University
Ikezaki, Hiroaki
Kyushu University
Suzuki, Sadao
Nagoya City University
Hosono, Akihiro
Nagoya City University
Mikami, Haruo
Chiba Cancer Center Research Institute
Nakamura, Yohko
Chiba Cancer Center Research Institute
Kubo, Michiaki
RIKEN
Wakai, Kenji
Nagoya University
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キーワード | Adrenomedullin
Receptor activity-modifying protein 2
Calcitonin-receptor-like receptor
Stroke
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資料タイプ |
学術雑誌論文
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抄録 | Aim: Stroke is associated closely with vascular homeostasis, and several complex processes and interacting pathways, which involve various genetic and environmental factors, contribute to the risk of stroke. Although adrenomedullin (ADM) has a number of physiological and vasoprotective functions, there are few studies of the ADM receptor system in humans. The ADM receptor comprises a calcitonin-receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs). We analyzed single nucleotide polymorphisms (SNPs) in the RAMP2 and CLR genes to determine their association with stroke in the light of gene-environment interactions.
Methods: Using cross-sectional data from the Japan Multi-Institutional Collaborative Cohort Study in the baseline surveys, 14,087 participants from 12 research areas were genotyped. We conducted a hypothesis-based association between stroke prevalence and SNPs in the RAMP2 and CLR genes based on data abstracted from two SNPs in RAMP2 and 369 SNPs in CLR. We selected five SNPs from among the CLR variants (rs77035639, rs3815524, rs75380157, rs574603859, and rs147565266) and one RAMP2 SNP (rs753152), which were associated with stroke, for analysis. Results: Five of the SNPs (rs77035639, rs3815524, rs75380157, rs147565266, and rs753152) showed no significant association with obesity, ischemic heart disease, hypertension, dyslipidemia, and diabetes. In the logistic regression analysis, rs574603859 had a lower odds ratio (0.238; 95% confidence interval, 0.076–0.745, adjusted for age, sex, and research area) and the other SNPs had higher odds ratios for association with stroke. Conclusions: This was the first study to investigate the relationships between ADM receptor genes (RAMP2 and CLR) and stroke in the light of gene-environment interactions in human. |
掲載誌名 |
Journal of Atherosclerosis and Thrombosis
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ISSN | 18803873
13403478
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出版者 | Japan Atherosclerosis Society
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巻 | 24
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号 | 12
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開始ページ | 1267
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終了ページ | 1281
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発行日 | 2017-12-01
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権利情報 | Copyright©2017 Japan Atherosclerosis Society
This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.(https://creativecommons.org/licenses/by-nc-sa/4.0/) |
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出版社版DOI | |
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言語 |
eng
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著者版フラグ |
出版社版
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部局 |
医学系
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