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ダウンロード数 : ?
ID 106000
著者
安井, 敏之 Department of Reproductive Technology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
松井, 寿美佳 Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
タニ, アンナ Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School
クニミ, コウタロウ Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School
ヤマモト, サトシ Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School
苛原, 稔 Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
women
testosterone
DHEA-S
menopause
資料タイプ
学術雑誌論文
抄録
Menopausal symptoms, bone loss, changes in lipid profiles and reduction of insulin sensitivity due to an abrupt decrease in circulating estrogen level are well known in women during the menopausal transition. On the other hand, the effect of androgen on women’s health has not been fully elucidated. Circulating levels of testosterone and dehydroepiandrosterone sulfate (DHEA-S) gradually decrease with age in postmenopausal women, although transient increases have been observed during the menopausal transition. High testosterone level has been suggested to be associated with increased risk of cardiovascular disease, increased triglyceride, insulin resistance and increase in the risk of developing breast cancer in postmenopausal women. Circulating DHEA-S level does not affect the risk of cardiovascular disease, mortality or lipid profiles in women. Female androgen insufficiency, which is characterized by the presence of reduced androgen level in circulation, leads to an impairment in sexual drive, reduced libido, depressed mood, and signs and symptoms of limited androgen exposure such as decreased muscle mass, reduced bone density and decreased sense of well-being. An appropriate level of androgen may play important roles in metabolic, psychological and sexual functions in women. In addition, the roles of testosterone and DHEA-S in women’s health may be different.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
59
1-2
開始ページ
12
終了ページ
27
並び順
12
発行日
2012-02
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院