| ID | 113577 |
| 著者 |
Iizuka, Shinji
Sanford-Burnham Medical Research Institute
|
| キーワード | matrix metalloproteinase
invasion
angiogenesis
head and neck squamous cell carcinoma
|
| 資料タイプ |
学術雑誌論文
|
| 抄録 | Extracellular matrix degradation by matrix metalloproteinases (MMPs) plays a pivotal role in cancer progression by promoting motility, invasion and angiogenesis. Studies have shown that MMP expression is increased in head and neck squamous cell carcinomas (HNSCCs), one of the most common cancers in the world, and contributes to poor outcome. In this review, we examine the expression pattern of MMPs in HNSCC by microarray datasets and summarize the current knowledge of MMPs, specifically MMP-1, -3, -7 -10, -12, -13, 14 and -19, that are highly expressed in HNSCCs and involved cancer invasion and angiogenesis.
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| 掲載誌名 |
Cancers
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| ISSN | 20726694
|
| 出版者 | MDPI
|
| 巻 | 6
|
| 号 | 1
|
| 開始ページ | 396
|
| 終了ページ | 415
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| 発行日 | 2014-02-13
|
| 権利情報 | © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
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| 出版社版DOI | |
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| 言語 |
eng
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| 著者版フラグ |
出版社版
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| 部局 |
歯学系
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