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タイトル別表記
The effects of insulin-induced hypoglycemia on the human AEP (Auditory Evoked Potential) and EEG
AEPおよび脳波へのinsulin低血糖の影響
著者
伊藤, 嘉信 徳島大学
河村, 一郎 徳島大学
大蔵, 雅夫 徳島大学
生田, 琢己 徳島大学
キーワード
auditory evoked potentials
EEG
hypoglycemia
insulin
noradrenaline
資料タイプ
学術雑誌論文
抄録
The effects of insulin-induced hypoglycemia on the central nervous system were studied by auditory evoked potential (AEP), with 8 schizophrenic patients (31~47 y.o.), during the 'kleine Insulinbehandlung'. In the three experimental session on different days, human regular insulin was injected subcutaneously to each patient, whose consciousness level was lowered to the stage of somnolence and recovered by intake of a glucose solution (100 g). EEG containig AEPs evoked by click simuli was derived from the two derivations (3rd ch : Cz→A1+2, 6th ch : Cz→T5). In the experimental session, EEG containing AEPs was recorded before and 20, 40, 60, 80, 100 and 120 min after the injection of insulin, and 20 min after intake of glucose. Consecutive changes of group mean AEP were studied. Individual AEPs were subjected to the component analysis, and to the statistical assessment together with EEG power %.
As a result, the middle latency components of AEP significantly reduced in latency and significantly increased in amplitude in the early stage after the injection of insulin, but significantly prolonged in latency in the latter stage. On the other hand, the long latency components of AEP significantly prolonged in latency and significantly decreased in amplitude throughout hypoglycemia. EEG power % significantly decreased in δ power% in the early stage, but significantly increased in δ and θ power % and significantly decreased in α and β power % in the latter stage. These results were attributed to the inhibitory effects of insulin-induced hypoglycemia on the cerebral cortex, and to the activation of the noradrenergic neurons responding to the hypoglycemia in the early stage. The results also indicate that the activated noradrenergic neurons are gradually declined during prolonged hypoglycemia.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
54
1
開始ページ
15
終了ページ
25
並び順
15
発行日
1998-02-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系